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Experimental Study of Sargassum Polysaccharide's Immune Modulatory Effect in Mice

CHEN Zhong-wei1,GAO Jian-feng2,HU Ting-jun3,HE Ying1,LIU Wei1,HU Shuai1,ZHAO Wu1,LI Bin1,LIANG Jia-xing1,ZHAO Wu1,GUAN Zhong-yi1(1.Veterinary Research Institute of Guangxi,Nanning 530001,China;2.Gansu Agriculture University,Lanzhou 730070,China; 3.School of Animal Science and Technology,Guangxi University,Nanning 530004,China)  
To investigate the immune-regulatory effects of sargassum polysaccharide(SP) on mice.The immunosuppressed model in mice was induced by dexamethasone(Dex).The TI,SI,lysozyme concentration and ACP,SOD,XOD,CAT,NO,MDA in thymus and spleen were analyzed to investigate the immune-regulatory effects of SP.The TI,SI,lysozyme concentration,ACP,NO was increased in normal and immunosuppressed mice following treated with SP.The CAT activity in immunosuppressed mice and the SOD activity in normal mice was both enhanced by treatment of SP.Furthermore,the MDA concentration in spleen in normal mice and the XOD activity in thymus and spleen in immunosuppressed mice was also enhanced following treatment of SP.Therefor,the SP could improve the immune function of the mice.
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