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《China Animal Husbandry & Veterinary Medicine》 2011-11
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Investigate the Effect of Aristolochic Acid Ⅰ in Inducing Apoptosis of the RTECs

PENG Xiao-lan,DONG Xiao-kai,LIAO Fang-fang,GAO Lei,ZHANG Zhong-wen,WU Guo-juan(Animal Science and Technology College,Beijing University of Agriculture,Beijing 102206,China)  
To investigate the effect of AAⅠ in inducing apoptosis of the renal tubular epithelial cells(RTECs) in mouse,mouse primary RTECs were cultured and identificated by morphology observation.After RTECs treated with or without AAⅠ,DNA ladder,flow cytometry analysis(FCAS) the apoptosis of the RTECs.Mouse RTECs could be successfully cultured,with the increase of AAⅠ,cells lost epithelial characteristics.After 24 h,20 to 80 μg/mL of AAⅠ stimulated RTECs,cells apparence late apoptosis.The apoptosis of mouse origin RTECs could be induced by AAⅠ,the degree of apoptosis is along with the increasing of AAⅠ action time and density.
【Fund】: 北京市自然科学基金项目(5102014、6092004);; 国家自然科学基金(30972215);; 北京市属高校人才强教计划资助项目(PHR2009-07135);; 北京市教委(KM201010020008)
【CateGory Index】: R692
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