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Anti-aging effect of polypeptides from Fructus Lycii on D-gal induced aging model mice and the possible mechanism

JIANG Wan-zhi,ZHANG Hong-quan(Department of Pharmacology,Medical School of Yangzhou University,Yangzhou 225001,China)  
Objective To study the anti-aging effect of polypeptides from Fructus Lycii(PFL)on D-galactose(D-gal)induced aging model mice and the possible mechanism.Methods Sixty ICR mice were randomly divided into normal control group,D-gal induced model group,PFL 200,400 and 800 mg/(kg·d)groups and vitamin E(VitE)100 mg/(kg·d)group.D-gal aging mouse model was established by cervicodorsal region subcutaneous injection with D-gal(10 mg/kg)once a day for five successive weeks.In the meantime,drugs were given by intragastric administration respectively in PFL and Vit E treatment groups.The effect of PFL on learning and memory ability of mice was observed.After 5 weeks,the superoxide dismutase(SOD)activity,malondialdehyde(MDA)content and telomerase activity in serum,heart,liver and brain tissues of mice were measured.Results Compared with normal control group,for aging model mice,the weight increasement declined,the number of errors in step-down test increased,the SOD and tolemerase activities in serum heart,liver and brain tissues dropped,and the MDA content was raised,P0.01.Compared with model group,for the mice in PFL and VitE treatment groups,the weight increasement rised(P0.01),the error number in step-down test decreased(P0.05),the SOD activity in serum,heart,liver and brain tissues enhanced,and the MDA content reduced(P0.01).The telomerase activity in serum and heart of 400,800 mg/(kg·d)PFL and VitE treatment groups also increased significantly than model group,while that in liver and brain did not change.Conclusion PFL have anti-aging effect on D-gal induced aging mice,and the action mechanism is related to the increasement of SOD activity,the decreasement of MDA content in serum,heart,liver and brain of D-gal aging mice,and the increasement of telomerase activity in serum and heart.
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