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《Journal of International Pharmaceutical Research》 2013-06
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Study on the diterpenoids from Radix Illicii Maji and their antiviral activity against Coxsackie B virus

WANG Ya-dan;ZHANG Gui-jie;QU Jing;LI Yu-huan;JIANG Jian-dong;YU Shi-shan;State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking UnionMedical College;Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences and Peking UnionMedical College;  
Objective To investigate the diterpenoids from the roots of Illicium majus(Radix Illcii Maji) and their antiviral activity against the Coxsackie B virus.Methods The compounds were isolated by column chromatography over silica gel,octadecylsilane chemically bonded silica gel(ODS),and Sephadex HL-20 coupled with preparative HPLC.Their stuctures were elucidated by spectroscopic analysis and the in situ dimolybdenum circular dichroism(CD) method,and their antiviral activities against the Coxsackie B3 virus were evaluated by cytopathic effect(CPE) method.Results Twelve diterpenoids were isolated from the roots of Illicium majus,which were identified as 4-epi-dehydroabietic acid(1),8,11,13,15-abietatraen-19-oic acid(2),jiadifenoic acids B(3),C(4),G(5) and I(6),majusanic acids B(7) and D(8),lambertic acid(9),angustanoic acids F(10) and G(11),and 13-hydroxy-8,11,13-podocarpatrien-19-oic acid(12).These diterpenoids displayed antiviral activity against the Coxsackie B3 virus,with IC50values of3.3-66.7 μmol / ml.Conclusion The antiviral activity and cytotoxicity of the diterpenoids relate to the substituent species and position.Compounds 3-6 and 9 were obtained from this plant for the first time.
【CateGory Index】: R284;R285
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