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《Modern Pharmacy and Clinic》 2009-06
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Preparation of self-emulsifying drug delivery system of angelica oil(the volatile oil from rhizome of Angelica sinensis)

LAN Yuan-yuan1,YAO Xiao-jun2,PAN Qin3(1.Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;2.The 196 Hospital of Chinese People's Liberation Army,Zhanjiang 524039,China;3.Tianjin Zhongxin Pharmaceutics Research Center,Tianjin 300457,China)  
Objective To investigate the optimum formula of self-emulsifying drug delivery system(SEDDS)angelica oil.Methods Solubility experiments,orthogonal screen,and a pseudo-ternary phase diagram were used for the preparation of SEDDS angelica oil.The optimum formula was determined by the emulsification degree and emulsion particle size.Results The best effect of emulsification was achieved when the formula was composed of angelica oil,Crodamol GTCC as oil phase,and Cremophor EL as the nonionic surfactant.Conclusion The optimum formula for SEDDS angelica oil is:Crodamol GTCC and Cremophor EL(the proportion is 7∶3),and angelica oil(wt% is 45.5%).
【CateGory Index】: TQ461
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