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《Drugs & Clinic》 2011-05
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Advances in study on icariin extraction,separation,and its anti-tumor mechanism

JIANG Ling-yun1,LIU Guang-ming1,CHEN Ke-xin2 1.School of Pharmaceutical and Chemical,Dali University,Dali 671000,China 2.School of Basic Medicine,Dali University,Dali 671000,China  
The methods for the extraction and separation of icariin,and the mechanism of anti-tumor activity of icariin are reviewed in this paper.There are various extraction and separation methods have been reported,such as ethanol extraction,ultrasonic,microwave,and high pressure;column chromatography(polyamide and macroporous resin adsorption methods),polyamide chromatography combined with ethyl acetate extraction and so on.Icariin and its derivatives show the potential inhibition on several tumor cells,such as lung cancer,gastric cancer,liver cancer,breast cancer,and leukemia cells.Previous study showed that icariin could induce the cell apoptosis through arresting the cell cycle,inhibiting the tumor cell signaling pathways,down-regulating cell factor,expression,and suppressing the tumor cell proliferation and metastasis.
【Key Words】： icariin extraction and separation antitumor tumor cell proliferation tumor cell metastasis apoptosis
【CateGory Index】： R284.2;R285
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