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《Drugs & Clinic》 2012-04
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Ways to find new anticancer drugs from Chinese herbal medicines

LIU Yan-ze,CHEN Shi-lin,MA Pei,XIAO Pei-gen Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100193,China  
Chinese herbal medicines(CHM) have been used for thousands of years and a great number of experiences used for human body have been obtained for treating various diseases including tumor.The rich CHM resources could provide the important material bases for new anticancer drugs.In this article,the ways to find new anticancer drugs based on the theory of traditional Chinese medicines(TCM) and modern scientific research from four aspects,which could promote the finding of new anticancer drugs from natural products.The four aspects are:to find the new anticancer drugs based on the theory of TCM,including heat-clearing and detoxicating medicine,blood-activating and stasis-resolving medicine,immune regulating medicine(qi-tonifying and reinforcing healthy qi medicine),and toxic CHM(toxicity against toxicity);to find the new anticancer drugs from lead compound;to find the new anticancer drugs from CHM extract by general screening and high-throughput screening,and to find the new anticancer drugs based on the pharmaphylogeny.
【Fund】: 科技部国际科技合作项目(2007DFB31610)
【CateGory Index】: R285
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【References】
Chinese Journal Full-text Database 2 Hits
1 LI Li,ZHOU Jiang,WANG Yi-cheng,et al(School of Basic Medical Science,Yunnan University of Traditional Chinese Medicine,Kunming Yunnan 650500);A Primary Exploration of Cytotoxic Effect of Jinghong Goniothalamus Chinensis Extract on Two Human Cancer Cell Lines in Vitro[J];Yunnan Journal of Traditional Chinese Medicine and Materia Medica;2013-02
2 HE Lilin1,SHEN Yongxiang2,ZHOU Zhongyin3,XU Yu4,LIU Ziliang1 1.Department of Oncology,Tianmen No.1 Renmin Hospital,Tianmen 431700,China,2.Department of Gastroenterology;3.Department of Gastroenterology,Renmin Hospital of Wuhan University;4.Department of Oncology,Zhongnan Hospital of Wuhan University;Curcumin Inhibits Human Gastric Cancer Growth in Xenograft Murine Model through Downregulation of HIF-1α/MMP-9 Pathway[J];Cancer Research on Prevention and Treatment;2013-08
【Citations】
Chinese Journal Full-text Database 10 Hits
1 MA Xue-mei et al(School of Biotechnology and Food Engineering,Anyang Institute of Technology,Anyang,Henan 455000);Advances in Studies on Codonopsis pilosula[J];Journal of Anhui Agricultural Sciences;2009-15
2 SONG Xiaodong YANG Yue YANG Junhou et alBinzhou Medical Universitg,Binzhou 256603;The effect of salvianolic acid B on a nontumorigenic human prostatic epithelial cell line[J];Journal of Binzhou Medical University;2007-01
3 CONG Yang1,HUANG Min2(1.Seven-year System of Dalian Medical University,Dalian 116044,China;2.Department of Microbiology,Dalian Medical University,Dalian 116044,China);Research progress of anti-tumor fundamental research and clinical application of lentinan[J];Journal of Dalian Medical University;2010-04
4 Su Ting-min WANG Min-juan RUAN Shi-bao(Pharmaceutical Department,Fjian University of Traditional Chinese Medicine,Fuzhou Fujian 350108,China);A Research Review of Chemical Constituents and Medical Function of Rhizoma Atractylodis Macrocepha1 Lae[J];Journal of Guiyang University(Natural Sciences);2008-02
5 He Ping; et al. (The 187th PLA Hospital Haikou, 571159);A PRIMARY REPORT OF SCREENING EXPERIMENTS ON ANTITUMOR OF 25 SPECIES OF HAINAN NATIVE PLANTS[J];Hainan Medical Journal;1994-02
6 LIU Jing,LIANG Jing yu *,XIE Tao(Department of Natural Medicinal Chemistry,China Pharmaceutical University,Nanjing 210009;china);Development of Rabdosia Rubescens〔Hemsl.〕Hara[J];Strait Pharmaceutical Journal;2004-02
7 CHEN Lu-xin~1,LI-Ning~1,ZHANG-Mian~1,ZHANG Chao-feng~1(Department of Pharmacognosy,China Pharmaceutical University,Nanjing Jiangsu 210038,China);Study of the Senecio Scandens Buch-Ham.[J];Strait Pharmaceutical Journal;2006-04
8 Yang Shuliang Wang Yang Chen Ning Harbin University of Commerce(Harbin,150076,China);Study on A canthopanax Senticosus Polysaccharide of the Present Situation and the Progress[J];Heilongjiang Medicine Journal;2006-06
9 Liang Guang~(1,2),Tian Jilai~1,Shao Lili~1,Yang Shulin~2,Li Xiaokun~(1*)(~1School of Pharmacy,Wenzhou Medicinal College,Wenzhou 325035;()~2Institute of Biotechnology,Nanjing University of Science and Technology, Nanjing 210094);Progress in the Research on SAR and Development of Antitumor Curcuminoids[J];Chemistry;2008-02
10 CHEN Ming,XIAO Weilin,LIU Dong,PENG Zhanying(Dept.of Urinary Surgery,the First Affiliated Hospital,Guangzhou University of TCM,Guangzhou 510405 Guangdong,China);Therapeutic Effect of Xiaoyu Sanjie Yi'ai Enema on Advanced Prostate Cancer[J];Journal of Guangzhou University of Traditional Chinese Medicine;2010-05
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LI Yi-ming~(1),SHEN Ye-shou~(1),WANG Qing~(2),JI Jun-qiu~(2)(1.School of Life Science,Anhui University,Hefei 230039,China;2.Hefei Lifang Pharmaceutical Company limited,Hefei 230088,China);Method of screening the drug for antienoplastic[J];Journal of Anhui University(Natural Sciences);2005-01
2 YUAN Yuan,YANG Yi,KAI Gui-qing ,PAN Jian(Engineering Research Center of Bio-process,Ministry of Education.PRC,Hefei 230009,China);Study on the Extractive Technique of Triterpenoids from Ganoderma lucidum[J];Anhui Chemical Industry;2007-04
3 Xu benbo Zhang Shijun Jiang Hongbo (College of Life Science,Yangtze University,Jingzhou,Hubei 434025,China);Study on the Microwave Assisted Extraction Technology of Polysaccharide from Chinese Yam[J];Anhui Agricultural Science Bulletin;2007-12
4 Wu Bao-feng Liu Lele Fang Zhihong Liu Xueyan (Department of biotechnology,Xinyang agricultural college,Xinyang,464000);Effects of Nutrition Factors on Mycelium Growth of 51427 in Ganoderma lucidum[J];Anhui Agricultural Science Bulletin;2008-06
5 Ren Yanli et al.(College of Chemistry and Biological Science,Yili Normal University,Yining 835000,China);Study on Bacteriostasis Test of Xinjiang Wild Walnut Leave Extract[J];Anhui Agricultural Science Bulletin;2012-13
6 Bao Yumei et al.(College of Agronomy and Biotechnology,Yunnan Agricultural University,Kunming 650201,China);Survey and Evaluation of Chinese Medicine Resources in Malong Peak Cangshan Mountain[J];Anhui Agricultural Science Bulletin;2012-13
7 WEI Cheng-xi et al (College of Life Science,Guizhou University,Guiyang,Guizhou 550025);The Fertilizer's Influence of Nitrogen,Phosphor and Kalium to the Prevention and Cure of Strobilanthes Cusia's Holing Illness[J];Journal of Anhui Agricultural Sciences;2006-11
8 WANG Zheng-de et al (Department of Biology,Nanyang Normal University,Nanyang,Henan 473061);Numerical Taxonomy of Medical Plant of Curcuma L. with Rough-set Theory[J];Journal of Anhui Agricultural Sciences;2006-17
9 RAO Huang-yun et al (East China Institute of Technology Department of Physics,Fuzhou,Jiangxi 344000);Determination of Geniposide in Fructus Gardeniae of Different Quality with HPLC[J];Journal of Anhui Agricultural Sciences;2006-17
10 YAO Xiao-hui (Department of Life Science,Shangqiu Normal College,Shangqiu,Henan 476000);Medicinal Efficacy of Plantain and Measuring Method of Valid Composition[J];Journal of Anhui Agricultural Sciences;2007-04
China Proceedings of conference Full-text Database 10 Hits
1 PENG Dong-hui~1 ZHANG Qi-xiang~2 LAN Si-ren~1 DONG Jian-wen~1 HUANG Hui~1 ZHOU Yu-zhen~1 (1 College of Landscape Architecture,Fujian Agriculture and Forestry University,Fuzhou 350002; 2 College of Landscape Architecture,Beijing Forestry University,Beijing 100083);Advances in the Research of Melastomataceae Plants[A];[C];2011
2 TANG Zhong-sheng,CHAI Xiang-hua,WU Ke-gang,LUO Ji (Faculty of Chemical Engineering and Light Industry,Guangdong University of Technology,Guangzhou Guangdong 510006);Studies on the Extraction of the Soluble Nitrogen from Lentinus Edodes by Physical Methods[A];[C];2012
3 ;Professor Liu Zhenhuan's experience on treating children with epilepsy by integration of traditional and Western medicine[A];[C];2011
4 ZHOU Chong~1 Liu Hui-jun~1 Cui You~2 SUN Xiu-yan~1 (1.School of Pharmacy,Yantai University,Yantai 264005,China; 2.Zhejiang Tianrui Pharmaceutical Company Limited,Ruian 325200,China);Separation and Identification of Curzerene in Curcuma Wenyujin Oil[A];[C];2011
5 Liu Hui-jun~1 Cui YOU~2 Zhou Chong~1 et al (ISchool ofPharmaey,Yantai Univety,Yantai 2640057Zhejiang Tianrui Pharmaceutical Co.,Ltd,Ruian 325200,China);Diseussion About the Content Determinationof Essential Oil of Curcuma Wenyujin[A];[C];2011
6 Fang Yuan1a,Jie Chen 2a,Wen-jin Wu 3,Su-zhen Chen 1,Xue-ding Wang 1 and Min Huang 1 1 Institute of Clinical Pharmacology,School of Pharmaceutical Sciences,Sun Yat-sen University,74 Zhongshan Road II,Guangzhou 510080,P.R.China,and 2 Department of Pharmacy,the First Affiliated Hospital,Sun Yat-sen University,58 Zhongshan Road II,Guangzhou 510080,China,and 3 Institution of Chinese Medical Science,University of Macau,Av.Padre Tomás Pereira S.J.,Taipa,Macao,P.R.China.;Effects of matrine and oxymatrine on catalytic activity of cytochrome P450s in rats[A];[C];2011
7 ;Study on the in vitro skin penetration and retention of podophyllotoxin solid lipid nanoparticle[A];[C];2011
8 ZHANG Xiao-ying LIU Jian-xue (College of Food and Bioengineering,Henan University of Science and Technology,Luoyang 471003,China);Determination of Total Flavonoids in Salsola collina Pall by Chromatometry[A];[C];2008
9 ZHANG Jin-mei, ZHAO Wei-jie, WANG Shi-sheng (State Key Laboratory of Fine Chemicals ,Dalian University of Technology, Dalian 116012, China);Studies on chemical constituents of curcuma aromatica salisb[A];[C];2005
10 (pharmacology Department of Huaihua medical college,Hunan,Huaihua,418000) Yang Lin Yang Zhixue;Per-experiment of Chemical Components for Stachys geobombycis[A];[C];2006
【Co-references】
Chinese Journal Full-text Database 3 Hits
1 QIN Hong-bin1,WEI Lei2,ZHANG Jing-wei3,TANG Jun-min4 1Medical School,Hubei Institute for Nationalities,Enshi 445000;2School of Basic Medical Science,Wuhan University,3Central South Hospital,Wuhan University,Wuhan 430071;4Department of Histology and Embryology,School of Basic Medical Science,Peking University,Beijing 100083,China;Study on functions and mechanism of curcumin in inducing gastric carcinoma BGC apoptosis[J];Chinese Journal of Cellular and Molecular Immunology;2011-11
2 TAN Xiangwen1,XIA Hong2,XU Jinhua3,CAO Jianguo4* 1.Department of Laboratory Animal Science,University of South China,Hengyang 421001,China;2.Institute of Cancer Research,University of South China,Hengyang 421001,China;3.Laboratory Center of Biochemistry and Molecular Biology,University of South China,Hengyang 421001,China;4.College of Medicine,Hu'nan Normal University,Changsha 410006,China;Inhibition of growth of human liver carcinoma xenograft tumor by 6,8-ditrifluoromethy-7-acetoychrysin in nude mice[J];China Medical Herald;2011-32
3 JIANG Miao-miao1,FENG Yi-fan1,ZHANG Xue2,YAO Xin-sheng3 1.Central Laboratory,Guangdong Pharmaceutical University,Guangzhou 510006,China 2.School of Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang 110016,China 3.Institute of Traditional Chinese Medicine & Natural Products,Jinan University,Guangzhou 510632,China;Chemical constituents from roots of Goniothalamus cheliensis (Ⅱ)[J];Chinese Traditional and Herbal Drugs;2011-12
China Proceedings of conference Full-text Database 1 Hits
1 Yang Genjin Gu Zhengbin Liang Huaqing Chen Haibin School of Pharmacy,Second Military Medical University,Shanghai 200433;Structural Determination of Cheliensisine by 1D and 2D NMR spectroscopy[A];[C];1998
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 YANG Sheng-li, HAN Shao-yin, ZHANG Qiao, DING Lan-ping, SONG Ai-yun, GONG Ya-ou, ZHANG Tan-mu (Department of Esophageal Cancer Research, Henan Medical University, Zhengzhou 450052, China);STUDY ON THE ANTIMUTAGENICTTY OF ORIDONIN[J];Carcinogenesis,Teratogenesis and Mutagenesis;2001-01
2 ZHANG Chun_ling, HU Jun_feng, QU Jiang_bin, et al.(School of Public Health, Shandong University, Jinan 250012 , Ch ina);STUDY ON ANTIMUTAGENICITY OF CHINESE HERBAL MEDICINE AND GREEN TEA TO BENZOAPYRENE AND NNK[J];Carcinogenesis,Teratogenesis and Mutagenesis;2003-02
3 LAI Ya-hui, MA Zhong-chun, YAN Hui-yi, et al(Medical College of Beihua University, Jilin 132013,China;Center for Disease Prevention and Controlof Jilin Province, Changchun 130021, China);Acute Toxicity and Genetic Toxicity Tests of Solanum Nigrum L Juice[J];Carcinogenesis,Teratogenesis and Mutagenesis;2005-01
4 CHEN Jun-xia 1 ,XIA Jun 2 ,LIU Ji-wei 3 ,CUI Xiu-yun 1,ˇ (1.Department of Biochemistry and Molecular Biology,Dalian Medical University,Dalian116027,Liaoning,China;2.Department of Biochemistry and Molecular Biology,Bengbu Medical College,Bengbu233003,Anhui,China;3.Department of Oncology,First Affiliated Hospital,Dalian Medical University,Dalian116011,Liaoning,China);Experimental Study on Apoptosis Induced by Ginsenoside Rg3 in Human MCF-7 Breast Cancer Cell Line[J];Carcinogenesis,Teratogenesis and Mutagenesis;2005-04
5 WANG Xin,HAI Chun-xu,LIANG Xin(Department of Toxicology,School of Military Preventive Medicine,the Fourth Military Medical University,Xi'an 710032,China);Activities of Acanthopanax Extracts in Vitro in Free Radical Models[J];Carcinogenesis,Teratogenesis & Mutagenesis;2009-02
6 Zhu Yongping ,Zhu Huijuan, Teng Suzhen, Huang Xingshuzhejiang Medical University,Hangzhou 310006;EMBRYOTOXlCITY AND TERATOGENICITY STUDY OFSOPHORIDINE IN WISTAR RATS[J];CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS;1995-03
7 YAN Rui-wen(Center of Analysis and Testing of China National Metrology Accredited Laboratory,Anhui University,Hefei 230039,China);Determination of 13 Elements in purslane by ICP-AES[J];Journal of Anhui University(Natural Sciences);2005-05
8 HU Fang-fang et al(Institute of Cellular and Molecular Biology,School of Life Science,Xuzhou Normal University,Xuzhou,Jiangsu 221116);Study on Tissue Culture of Changium smyrnioides Wolff Leaf[J];Journal of Anhui Agricultural Sciences;2007-08
9 YANG Run-ya et al(College of Life Science,Ludong University,Yantai,Shandong 264025);Preliminary Study on the Isolation and Fungicidial Activity of Fructus forsythiae Endophyte[J];Journal of Anhui Agricultural Sciences;2007-15
10 ZHAO Qing-fang et al(College of Life Sciences,Northwest Normal University,Lanzhou,Gansu 730070);Study on Allelopathy of Water Infusion from Codonopsis Pilosula on Different Crops[J];Journal of Anhui Agricultural Sciences;2007-24
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