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《Drugs & Clinic》 2012-04
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Ways to find new anticancer drugs from Chinese herbal medicines

LIU Yan-ze,CHEN Shi-lin,MA Pei,XIAO Pei-gen Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100193,China  
Chinese herbal medicines(CHM) have been used for thousands of years and a great number of experiences used for human body have been obtained for treating various diseases including tumor.The rich CHM resources could provide the important material bases for new anticancer drugs.In this article,the ways to find new anticancer drugs based on the theory of traditional Chinese medicines(TCM) and modern scientific research from four aspects,which could promote the finding of new anticancer drugs from natural products.The four aspects are:to find the new anticancer drugs based on the theory of TCM,including heat-clearing and detoxicating medicine,blood-activating and stasis-resolving medicine,immune regulating medicine(qi-tonifying and reinforcing healthy qi medicine),and toxic CHM(toxicity against toxicity);to find the new anticancer drugs from lead compound;to find the new anticancer drugs from CHM extract by general screening and high-throughput screening,and to find the new anticancer drugs based on the pharmaphylogeny.
【Fund】: 科技部国际科技合作项目(2007DFB31610)
【CateGory Index】: R285
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