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《Drugs & Clinic》 2013-01
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Research progress in metabolites of active constitutes from Epimedii Herba

HAN Hui 1,SHAN Qi 2,3,ZHOU Fu-jun 2,3,ZHANG Xin-xin 2,3,HOU Wen-bin 2,3 1.Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China 2.Tianjin Institute of Pharmaceutical Research,Tianjin 300193,China 3.State and Local Joint Engineering Laboratory of Preparation and Quality Control Techniques for TCM (Tianjin),Tianjin 300193,China  
Epimedii Herba is one of the traditional Chinese materia medica with the function of invigorating kidney,strengthening yang,and eliminating wind and dampness.Flavonoid glycosides of icariin as the representative,are the main active chemical components in Epimedii Herba.Recent studies have found that the material basis of these compounds may be their metabolites in vivo.The paper reviews the research progress in the metabolites of the active constituents in Epimedii Herba,which could provide the effective guidance for further understanding their mechanism and the development of the related drugs.
【Key Words】： Epimedii Herba icariin epimedin A baohuoside Ⅰ metabolites
【Fund】： 国家重大新药创制科技重大专项(2009ZX09102)
【CateGory Index】： R284.1
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