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《Drugs & Clinic》 2013-02
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Chemical constituents from Astragalus membranaceus var.mongholicus

SUN Jie1,2,ZHANG Lei1,2,ZHANG Xiao-long1,2,YAN Rui-qing1,2,CHAI Xin1,2,WANG Yue-fei1,2 1.Tianjin State Key Laboratory of Modern Chinese Medicine,Institute of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China 2.Research and Development Center of Traditional Chinese Medicine,Tianjin International Joint Academy of Biotechnology and Medicine,Tianjin 300457,China  
Objective To study the chemical constituents in petroleum ether,methylene chloride,and ethyl acetate fractions in the alcohol extract from the dried roots of Astragalus membranaceus var.mongholicus.Methods The constituents were separated and purified by silica gel,Sephadex LH-20 column chromatography,and preparative HPLC.Their structures were elucidated by physicochemical properties and spectroscopic data.Results Fourteen compounds were obtained and identified as pratensein(1),formononetin(2),formononetin-7-O-β-D-glucoside(3),calycosin(4),calycosin-7-O-β-D-glucoside(5),(6aR,11aR)-3-hydroxy-9,10-dimethoxypterocarpan(6),(6aR,11aR)9,10-dimethoxypterocarpan-3-O-β-D-glucoside(7),astragaloside Ι(8),acetylastragaloside Ι(9),astragaloside ΙΙ(10),isoastragaloside ΙΙ(11),adenine(12),β-sitosterol(13),and daucosterol(14).Conclusion Flavonoids and saponins are the essential components in A.membranaceus var.mongholicus.
【Fund】: 天津市科技创新体系及条件平台建设计划项目(10SYSYJC28900);; 天津市高等学校科技发展基金计划项目(20090223)
【CateGory Index】: R284.1
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