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《Health Medicine Research and Practice》 2014-02
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Clinical Effect and the Mechanism of Oral Lactulose on Acute and Sub-acute Hepatic Failures

LIU Gang;JIANG Yu;CHEN Ying-xiao;University Town Hospital of Chongqing Medical University;Department of Infectious Diseases,The First Affiliated Hospital of Wenzhou Medical University;  
Objective To observe the effects of oral lactulose on the treatment of acute and sub-acute hepatic failures and to discuss the possible mechanism of endogenous hydrogen as oral lactulose to treat acute and subacute hepatic failures.Method 54cases of patients with acute and sub-acute hepatic failures were divided into a control group(20cases)and a lactulose treatment group(34cases).The control group was received conventional medical treatment and the treatment group was given conventional medical treatment and 8-week treatment of oral lactulose.Results There were two cases of spontaneous bacterial peritonitis in the treatment group and 14cases in the control group,and the difference was statistically significant(P0.05).Comparing with the control group,the levels of serum total bilirubin(TBIL)and blood ammonia were higher in the treatment group and the differences were statistically significant(P0.05).The time for prothrombin activity to rise to over 40%in patients of the treatment group was shorter than that of the control group and the difference was statistically significant(P0.05).Conclusion The long-term use of lactulose to treat acute and subacute hepatic failures can significantly improve liver function and lower blood ammonia in patients.The possible mechnaicam is generating endogenous hydrogen.
【CateGory Index】: R575.3
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