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《Health Medicine Research and Practice》 2014-02
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Clinical Effect and the Mechanism of Oral Lactulose on Acute and Sub-acute Hepatic Failures

LIU Gang;JIANG Yu;CHEN Ying-xiao;University Town Hospital of Chongqing Medical University;Department of Infectious Diseases,The First Affiliated Hospital of Wenzhou Medical University;  
Objective To observe the effects of oral lactulose on the treatment of acute and sub-acute hepatic failures and to discuss the possible mechanism of endogenous hydrogen as oral lactulose to treat acute and subacute hepatic failures.Method 54cases of patients with acute and sub-acute hepatic failures were divided into a control group(20cases)and a lactulose treatment group(34cases).The control group was received conventional medical treatment and the treatment group was given conventional medical treatment and 8-week treatment of oral lactulose.Results There were two cases of spontaneous bacterial peritonitis in the treatment group and 14cases in the control group,and the difference was statistically significant(P0.05).Comparing with the control group,the levels of serum total bilirubin(TBIL)and blood ammonia were higher in the treatment group and the differences were statistically significant(P0.05).The time for prothrombin activity to rise to over 40%in patients of the treatment group was shorter than that of the control group and the difference was statistically significant(P0.05).Conclusion The long-term use of lactulose to treat acute and subacute hepatic failures can significantly improve liver function and lower blood ammonia in patients.The possible mechnaicam is generating endogenous hydrogen.
【CateGory Index】: R575.3
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 GU Ximing,GUO Lv.Department of Surgery,Kunshan Hospital of Traditional Chinese Medicine,Kunshan,Jiangsu Province(215300);Hydrogen Breath Test Measuring Oro-cecal Transit Time[J];Chinese Journal of Gastroenterology;2007-07
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 WANG Jin-Huan, LI Juan, FENG Yan-Mei, et al (Department of Serious Illness Medicine Inpatient Area, Beijing You'an Hospital, Capital Medical University, Beijing 100069);Energy metabolism and clinical features of patients with sub-acute-on-chronic alcoholic liver failure[J];Beijing Medical Journal;2011-12
2 XUN Yun-hao1,2,GUO Jian-chun1,CHEN Zhi-yun3,LIU Ying4,SHI Wei-zhen1,SHI Jun-ping1(1The 6th Hospital Affiliated to Zhejiang University of Traditional Chinese Medicine,Hangzhou 310014,China;2The 6th Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200233,China;3Institute for Degistive Disease,Traditional Chinese Medicine Hospital of Zhejiang,Hangzhou 310006,China;4Zhejiang Chinese Medical University,Hangzhou 310053,China);Dampness-heat and yin-deficiency constitution of TCM associated with chronic severe hepatitis B[J];China Journal of Traditional Chinese Medicine and Pharmacy;2011-07
3 WANG Hui-fen, SU Hai-bin Liver Failure Treatment and Research Center, 302 Hospital of PLA, Beijing 100039, China;Progress of the treatment of liver failure[J];Infectious Disease Information;2010-02
4 WANG Yu-ming, TANG Ying-zi, DENG Guo-hong, YAN Ze-hui Institute of Infectious Diseases of PLA, Southwest Hospital, Third Military Medical University, Chongqing 400038, China;Research progress of complications in liver failure[J];Infectious Disease Information;2010-02
5 WANG Yu-ming,ZHU Peng PLA Institute of Infectious Diseases,Southwest Hospital,Third Military Medical University,Chongqing 400038,China;Recent advances in controversial issues of liver failure[J];Infectious Disease Information;2012-03
6 YE Pei-yan,MIAO Hui,YANG Zong-guo,CHEN Xiao-rong,LU Yun-fei,LIU Cheng, Shanghai Public Health Clinical Center(Affiliated to Fudan University),Shanghai 201508,China;Clinical Observation on Chronic Severe Hepatitis at Early-Middle Stage Treated with Retention Enema of JieDu ZhuYuFang[J];Western Journal of Traditional Chinese Medicine;2012-07
7 Peng Hui1,Chen Weixian1,Chang Lin2,Chen Min2(1Department of Laboratory Medicine,Second Affiliated Hospital,Chongqing Medical University;2Key Laboratory of Molecular Biology for Infectious Diseases cofounded by Chongqing and Ministry of Education,Institute for Viral Hepatitis,Chongqing Medical University,Chongqing,400010,China);Proinflammatory cytokine production of TCR γδT cells in peripheral blood of patients with HBV-associated acute-on-chronic liver failure,and correlation analysis between cell proportion and clinical parameters[J];Journal of Third Military Medical University;2012-17
8 WU Guo-wu,HUANG Zhen,YANG Quan-lie.Department of Medical Oncology,Meizhou People′s Hospital,Meizhou 514031,China;The application of lamivudine in chemotherapy for cancer patients with HBV infection[J];Guangdong Medical Journal;2012-17
9 LIN Tao1,HUANG Guo-qing2,WEN Ming-xiang2,LIAO Xiao-xing2(1 Department of Emergency,the Second People′s Hospital of Guilin City,Guilin 541001,China; 2 Department of Emergency,the First Affiliated Hospital,Sun Yat-Sen University,Guanghou 510080,China);Effects of Intraperitoneal Injection with Saturated Hydrogen Saline or Hydrogen Gas on Hydrogen Metabolism in Rats[J];Guangxi Medical Journal;2012-11
10 Peng Hui;Chang Lin;Wang Lei;Chen Min;Department of Clinical Laboratory,Second Affiliated Hospital,Chongqing Medical University;Institute for Viral Hepatitis,Key Laboratory of Molecular Biology for Infectious Diseases,Ministry of Education,Chongqing Medical University;;The change of NK or NKT cells in the peripheral blood of patients with HBV-associated acute-on-chronic liver failure[J];Chongqing Medicine;2013-31
China Proceedings of conference Full-text Database 1 Hits
1 ;病毒因素及其防治在慢性乙型肝炎肝硬化中的地位[A];[C];2009
【Secondary Citations】
Chinese Journal Full-text Database 5 Hits
1 WANG Yuming; CHEN Yaokai; GU Changhai, et al. (Center for Infectious Diseases, Southwest Hospital, Third Military Medical University ,Chongqing 400038, China);Reevaluation of the nomenclature and diagnostic criteria in 477 patients with severe hepatitis[J];CHINESE JOURNAL OF HEPATOLOGY;2000-05
2 CHEN Cong-xin, GUO Shun-ming, LIU Bo, YANG Jia-hong, XU Ning, LIU Ke-wan. Department of Infectious Diseases, 105th Hospital of People's Liberation Army, Hefei 230031, China;Glycocorticosteroid administration prevents fulminant hepatic failure occurrence in patients with chronic hepatitis B of severe degree[J];Chinese Journal of Hepatology;2003-01
3 Lamivudine Clinical Practice Group..;Lamivudine treatment consensus from relative experts in 2004[J];Chinese Journal of Hepatology;2004-07
4 SUN Yan ling *,ZHAO Jing min,ZHOU Guang de,WANG Song shan, LI Wen shu, MENG Er hong,ZHANG Tai he,ZHANG Ling xia,CHEN Ju mei,ZHU Chuan lin,HUANG PU Yu shan *Department of Pathology,The No.302 Hospital of PLA, Beijing 100039, China Corresponding author: ZHAO Jing min,Tel:(010)66933259;Cut-off period of subclassification and pathological features of severe hepatitis based on clinical and pathological analyses[J];Chinese Journal of Experimental and Clinical Virology;2003-03
5 Yin Wenya, Xiao Yuhua, Huang Chengyu, et al. Department of Nutrition and Food Hygiene West China University of Medical Sciences Chengdu 610041;Determination of Food Oral colon Transit Time with Breath Hydrogen Test[J];CHINESE JOURNAL OF PREVENTIVE MEDICINE;1998-05
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