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《JOURNAL OF CHEMICAL ENGINEERING OF CHINESE UNIVERSITIES》 2000-02
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Kinetic Model of Affinity Membrane Adsorption for Biomolecules in Stacked Flat-sheet Module

CHAI Hong, CHEN Huan-lin (College of Chemical and Material Engineering, Zhejiang University, Hangzhou 310027, China)  
A kinetic model for biomolecules adsorption to stacked flat-sheet affinity membrane was formulated based on adsorption kinetic equation and mass balance. The model equations are solved by Crank-Nicholson implicit finite difference methods. The results obtained from model simulation show that the breakthrough is influenced by dispersion coefficient, feed concentration, forward direction rate constant, membrane thickness, ligand concentration and flow rate. Breakthrough profiles are quantitatively discussed in terms of protein recovery and ligand utilization ratio. The experimental data from literature were used for model correlation. The result shows that when the dimensionless concentration is less than 0.4, the model simulation is in fair agreement with the experimental data but when the dimensionless concentration is higher than 0.4, the deviation became larger, and the saturation time predicted by the model is less than the experimental value.
【Fund】: 国家自然科学基金!(29676038)
【CateGory Index】: O643
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Chinese Journal Full-text Database 4 Hits
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【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LU Min ,GUAN Xiaohui ,LU Guang-jie,QI Jian-hua(Department of Chemical Engineering, Northeast China Institute of Electric Power Engineering, Jilin City, 132012; Beijing Longyuan Environmental Engineering Co., Ltd,Beijing City 100761 ;. Hei Longjiang Province Electric Power Development Co. ,Harbin City 150090);Present Situations about Enhanced Research and Application of Membrane Micro-filtration[J];Journal of Northeast China Institute of Electric Power Engineering(Natural Science Edition);2004-04
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【Secondary Citations】
Chinese Journal Full-text Database 4 Hits
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