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Introduction to the Theory and Practice of Metabolic Control Analysis

Ling Li Chen Guangzhi Zhou Hezhi (College of Biotechnology & Sugar Industry Engineering, Guangxi Univ.,10 Xixiangtanglu,Nanning,Guangxi,530004)  
Metabolic Control Analysis (MCA) is a quantitative analysis theory and an experimental methodology with the systemic view for metabolic regulation and control. MCA reveals that control is an attribute of metabolic systems by the abstraction of real metabolic phenomenon, and can quantify the contol with enzyme kinetics. The traditional unique rate limiting step is invalidated, and the control exerted by each step (enzyme) in a pathway is varied with the steady states in which the pathway works. Evaluating the control coefficients theoretically or experimentally is to characterize the properties of the metabolic networks. The coherence of MCA, computer simulation and rapid measure techniques will be the powerful metheod for metabolic engineering. There are some limitations of MCA which shall be improved by theoretical development and expansion of the applications to accumulate examples.
【CateGory Index】: Q591.1
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