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《Journal of Guangxi Normal University(Natural Science Edition)》 2013-02
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Protection of Flavonoids Extracted from Siraitia grosvenorii Leaves to Different Tissue Membranes in Rats During Exhaustive Exercise

JIANG Feng1,2,3,DENG Qi-lie1,CHEN Mei1,2,MO Wei-bin1,2,YANG Yong-liang1(1.College of Sports Education,Guangxi Normal University,Guilin Guangxi 541004,China;2.Guangxi Key Laboratoryfor the Chemistry and Molecular Engineering of Medicinal Resources/Ministry of Education of China,Guangxi NormalUniversity,Guilin Guangxi 541004,China;3.Lijiang College,Guangxi Normal University,Guilin Guangxi 541004,China)  
To provide a theoretic evidence for exploitation and application of Siraitia grosvenorii leaves resources,the protection effect of flavonoids extracted from Siraitia grosvenorii leaves in response to oxidative stress injury was studied.Forty healthy male Sprague-Dawley rats(body weigh of 180~220 g,aged 2~3 months) were randomized into five groups,each consisting of 8 rats:the quiet control group,the pro-quiet exhaustive group,the pro-administration exhaustive group,the pro-training exhaustive group and the pro-administration-training exhaustive group.Drug-treated groups were administrated(i.g.) the solution of physiological saline paired with flavonoids extracted from Siraitia grosvenorii leaves(20 g/L) at a dose of 10.0 mL/kg body weight per day;while other groups were administrated of pure physiological saline at the same dose.After the incremental swimming training of 28 d,rats in exhaustion groups were bore their own weight by 3% and swam to exhaustion.Rats(including the rats in quiet control group) were killed by decapitation immediately after accurately recorded the exhaustive time.Blood,heart,liver and quadriceps tissues were sampled for subsequent analysis of enzymes' activities(GOT,GPT and CK),and observation of histopathological changes with microscope.The results showed that flavonoids extracted from Siraitia grosvenorii leaves can obviously increase the activities of GOT,GPT and CK in heart,liver and quadriceps tissues,decrease these corresponding enzymes' activities in plasma.The cell membranes of heart,liver and quadriceps tissues in drug-treated groups are much more integrated than that of non drug-treated groups.The ratios of rupture and deformation are greatly reduced in drug-treated groups.The conclusion indicates that flavonoids extracted from Siraitia grosvenorii leaves can help to protect the cell membranes of heart,liver and quadriceps tissues,ensure the integrity and fluidity of the membranes.
【Fund】: 广西科学研究与技术开发计划项目(桂科转11107022-3);; 广西药用资源化学与药物分子工程重点实验室/教育部重点实验室开放课题(CMEMR2012-B04);; 广西医药产业人才小高地项目(1109)
【CateGory Index】: R285.5
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