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《Journal of Guangxi Medical University》 2001-06
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STUDY OF COIX SEED EXTRACT IN ITS EFFECT ON INDUCING PROLIFERATION,APOPTOSIS AND p53 EXPRESSION IN HUMAN HEPATOCELULAR CARCINOMA

Wei Changyuan,Li Ting,Tang Zongping,et al (Affiliated Cancer Hospital, Guangxi Medical University,Nanning,530021 China)  
Objective:To study the apoptosis induced by KLT in human hepatocellular carcinoma Methods:MTT,immunohistochemical and electronic microscopic methods were used in 34 cases to observe primary liver cancer treated with KLT in vitro,compared to the control group Results:① KLT can inhibit hepatocellular carcinoma cell proliferation up to 30% ② Comparing to the control group, hepatocellular carcinoma cells treated with KLT showed significant apoptosis and p53 expression(P0 05) ③ under the electronic microscope,the characteristics of apoptosis,such as the formation of cell membrane blebs and apoptotic bodies were observed in hepatocellular carcinoma cells Conclusion:KLT can induce apoptosis in hepatocellular carcinoma cells It may increase the p53 gene expression
【Fund】: 广西区卫生厅课题 ( z982 8)
【CateGory Index】: R735.7
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