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《Journal of Guangxi Medical University》 2007-01
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APPLICATION OF SUCROSE-BASED POLYMERS AS SUSTAINED-RELEASE TABLETS CARRIER

Wei Yuanan,Deng Minjun,Yao Pingjia.(College of Life Science and Technology, Guangxi University, Nanning 530004 China)  
Objective: To study the feasibility of sucrose-based polymer(SBP) as sustained-release formulation carrier. Methods: Sustained-release tablets containing fenoprofen calcium were prepared with different molecular weight(MW) of SBP. The sustained-release tablet's release rate in artificial intestinal juices was measured intermittently by ultra-violet spectrophotometer and the relationship between the release rate and time was described in a curve. Result: The fenoprofen calcium could be slowly released in 12h steadily. The larger molecular weight of SBP, the slower of the release rate. Conclusion: SBP can be used for sustained-release tablets, and when the MW of SBP is 79.4K, the effect of optimal slow release can be achieved.
【Fund】: 国家自然科学基金资助项目(20366002-2)
【CateGory Index】: R944
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