Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Guangxi Medical University》 2007-02
Add to Favorite Get Latest Update


Wang Mingjun.(Department of Nephrology, the First Affiliated Hospital, Guangxi Medical University, Nanning 530021 China)  
Objective: To study the effect of leflunomide (Lef)on the process of renal interstitial fibrosis caused by unilateral ureteral obstruction(UUO) in rats. Methods: 24 Sprague-Dawley rats underwent UUO and were randomly divided into two groups: UUO group (n=12) and Lef-treated group (=12). Then they respectively received vehicle or Lef(10 mg/kg·d-1 by daily gastric gavage)during the 14 days following surgery. Additional 12 rats received sham operation. Six rats of each group were killed respectively in 7 and 14days after surgery. Immunohistochemistry was performed on renal tissue for proliferating cell nuclear antigen(PCNA),α-smooth muscle actin(α-SMA),which was cytosheletal marker of Myoibroblast(Myo) and collagenⅠ,Ⅲ. Histological changes were also observed by HE and Masson stain. Result: In comparison with the UUO group, α-smooth muscle actin, PCNA and collagenⅠ,Ⅲ deposition were all significantly reduced by Lef treatment. Conclusion: Lef can prevent renal interstitial fibrosis process in UUO rats by reducing interstitial Myo infiltration and collagenⅠ,Ⅲ deposition . Lef may be used to slow the progression of chronic renal disease.
【Fund】: 广西科学研究与技术开发应用基础研究专项项目(桂科基01560022)
【CateGory Index】: R692
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 1 Hits
1 HUANG Hongling, ZHANG Guoqiang,YE Rengao, et al. Department of Nephrology, Key Clinical Kidney Research Institnte of Minitry of Health, First Affiliated Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou 510089, China;The role of cell proliferation and apoptosis in renal tubulointerstitial fibrosis caused by unilateral ureteral obstruction[J];Chinese Journal of Nephrology;2000-01
Chinese Journal Full-text Database 10 Hits
1 LI Hong-Guang CAI Yuan-Ju ZOU Jin-Hui JING Mei-Lian LIU Yi(Medical College,Shaoguan University,Shaoguan,Guangdong 512026,China);The Effects of High-Sucrose and High-Fat Diet on Tubulointerstitial Fibrosis in New Zealand White Rabbits[J];Chinese Journal of Zoology;2010-01
2 REN Yun-zhuo,HAO Jun,SI Yong-hong,et al.(Department of Pathology,Hebei Medical University,Shijiazhuang 050017,China);Effect of TGF-β_1 on human kidney tubular epithelial cells′ aptoptosis and cell proliferation dependent of the smad signaling pathway[J];Chongqing Medicine;2007-20
3 ZHANG Jian-Jiang,YI Zhu-Wen,DANG Xi-Qiang, HE Xiao-Jie,WU Xiao-Chuan.Laboratory of Pediatric Nephrology,Second Xiangya Hospital,Cenrtal South University,Changsha 410011,China;Mobilization effects of SCF along with G-CSF on bone marrow stem cells and endothelial progenitor cells in rats with unilateral ureteral obstruction[J];Chinese Journal of Contemporary Pediatrics;2007-02
4 ZHOU Jian-song1,CHEN Gang2,SHEN Ye-qu2,WU Mei2,HE Li-qun2 1.Department of Nephrology,the Third Affiliated Hospital of Nantong University,Wuxi 214041,Jiangsu,China2.Department of Nephrology,Shuguang Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Effects of valsartan on renal interstitium fibrosis in rats after unilateral ureteral obstruction[J];Academic Journal of Second Military Medical University;2010-03
5 ZENG Jian-ying,HE Feng,WANG Yin,DING Hai-yan,TONG Jun-rong,LUO Zheng-mao.Department of the Second Geronotology,General Hospital of Guangzhou Military Command of PLA,Guangzhou 510010,China.;Effects of astragalus mongholicus on expression of snail in rats with cyclosporin A-induced nephropathy[J];Guangdong Medical Journal;2011-08
6 PENG Xiao-lan,DONG Xiao-kai,LIAO Fang-fang,GAO Lei,ZHANG Zhong-wen,WU Guo-juan(Animal Science and Technology College,Beijing University of Agriculture,Beijing 102206,China);Investigate the Effect of Aristolochic Acid Ⅰ in Inducing Apoptosis of the RTECs[J];China Animal Husbandry & Veterinary Medicine;2011-11
7 SUN Jian~ 1 ,TAO Li-jian~ 1,* , JIN Ou~ 2 , NING Wang-bin~ 1 ,DAMU Tang~ 3 (1.Department of Nephrology, Xiangya Hospital, Central South University; 2.Department of Pathology, Basic Medical College, Central South University, Changsha 410008;3.Department of Medicine, McMaster University, Hamilton, Ontario L8N 4A6, Canada);Expression of p27 in rat kidney with unilateral ureteral obstruction and the therapeutic effect of enalapril[J];Journal of Central South University(Medical Sciences);2006-05
8 LI Fangmei,SONG Enfeng (Renmin Hospital of Wuhan University,Wuhan 430060);Effect of Lycopus on Expression of NF-κB and VEGF in Rats with Unilateral Ureteral Obstruct[J];Journal of Hubei University of Chinese Medicine;2010-03
9 ZHOU Jiansong,CHEN Gang,WU Mei,et al Nephrology Department of Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai (200021);Effects of "Kang Xian Ling Decoction-Ⅱ" on Renal Tubule Epithelial Mesenchymal Transdifferentiation in Rats After Unilateral Ureteral Obstruction[J];Chinese Journal of Integrated Traditional and Western Nephrology;2008-11
10 HAN Lin1,QIN Jian-guo2,CHEN Zhi-qiang3,XU Qing-you3,LI Peng-tao4(1 School of Fundamental Medicine,Beijing University of Chinese Medicine,Beijing 100029;2 Dongfang Hospital,Beijing University of Chinese Medicine;3 Institute of Integration of Chinese and Western Medicine,Hebei Medical University;4 Dongzhimen Hospital,Beijing University of Chinese Medicine);Influence of Biejiajian Pills on cell proliferation in rats with renal interstitial fibrosis[J];Journal of Beijing University of Traditional Chinese Medicine;2009-07
Chinese Journal Full-text Database 10 Hits
1 Tang Li,Cao Xueying,Zhao Wei,et al (Department of Nephrology,General Hosipital of Chinese PLA,Beijing 100853);A randomized control trail of leflunomide and mycophenolate mofeil treatment in refractory nephropathy syndrome[J];Beijing Medical Journal;2004-05
2 ZHAO Ban,LI Hui-lin,LIAN Yao-guo,et al(Department of Nephrology,Peking Union Medical College Hospital,Beijing 100730);Study in altered expression of integrin-linked kinase in Epithelial-mesenchymal transition of HKC induced by MCP-1[J];Beijing Medical Journal;2009-03
3 GAO Zhi-qing1,KANG Hao-peng2,ZHANG Jun3,ZHANG Lin-qi1(1The First Affiliated Hospital of Henan University of TCM, Henan 450003, China; 2The Preclinical Medical College of Henan University of TCM, Henan 450008, China; 3The Third Affiliated Hospital of Henan University of TCM, Henan 450003, China);Influence of BushenHuoxuefang on the Expression of Platelet Derived Growth Factor BB in Renal Interstitial Fibrosis Rats[J];China Journal of Traditional Chinese Medicine and Pharmacy;2010-02
4 XU Jing, SU Hong-li, WANG Jun-hong, ZHANG Chun-hong Department of Endocrinology, Second Affiliated Hospital, Xi'an Jiaotong University College of Medicine, Xi'an 710004, China;Role of CD4~+CD25~+Foxp3~+ regulatory T cells in type 2 diabetic nephropathy[J];Journal of Southern Medical University;2009-01
5 Yi Li,Shu Guiyang,Chen Youming,et al.Fujian Provincial Hospital,Fuzhou 350001,China;The expression and significance of transforming growth factor-β_1 in rats with renal tubulointerstitial fibrosis[J];Fujian Medical Journal;2007-04
6 JIN Xiao-ming*, YE Fei, ZHANG Lei, ZHANG Feng-shan. *Department of Pathology, Harbin Medical University, The Second Affiliated Hospital of Harbin Medical University, Heilongjiang 150086, China;The analysis of renal lesions transformation of 21 lupus nephritis cases treated with leflunomide by repeated renal biopsies[J];Chinese Journal of Rheumatology;2005-03
7 Shi Weiping Changshu College of Jiangsu Province, Changshu, Jiangsu (215500);Clinical Significance of Measurements of Related Serum Cytokines (IL-6, sICAM-1, M-CSF) Levels After Urokinase Therapy in Patients with Acute Myocardial Infarction[J];Journal of Radioimmunology;2004-04
8 LI Hong,LI Jia-xuan,ZHANG Zhi-zhe,HUANG Tian-xia(The First Hospital of Nanning City,Guangxi Nanning 530022,China);Changes of CD4~+ CD25~+ Regulatory T Cells in Peripheral Blood of Diabetes Mellitus Complicated with Pulmonary Infection and Its Significance[J];Guangxi Medical Journal;2011-02
9 Yan Run.Division of Nephrology,The affiliated Hospital of Guiyang Medical College,Guiyang 550004,Guizhou,China;The expression and significance of PDGF-B in rats with renal interstitial fibrosis[J];Guizhou Medical Journal;2009-06
10 WANG Lin-na,TAO Li-jian,NING Wang-bin(Department of Nephrology,Xiangya Hospital,Central South University,Changsha 410008,China);Effect of enalapil on renal interstitial fibrosis in rats with unilateral ureteral obstruction[J];Journal of Central South University(Medical Sciences);2008-09
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Zheng Guoqiang, Ye Rengao , Cheng Yongxinng, et al. Institute of Kidney, Sun Yat-sen University of Medical Sciences, Guangzhou 510089;Comparison of growth and apoptosis of fibroblasts derived from kidneys with and without interstitial fibnwis[J];Chinese Journal of Nephrology;1997-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved