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《Journal of Guangxi Medical University》 2007-02
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EXPERTIMENTAL STUDY FO LEFLUNOMIDE IN PREVENTING RENAL INTERSTITIAL FIBROSIS IN RATS

Wang Mingjun.(Department of Nephrology, the First Affiliated Hospital, Guangxi Medical University, Nanning 530021 China)  
Objective: To study the effect of leflunomide (Lef)on the process of renal interstitial fibrosis caused by unilateral ureteral obstruction(UUO) in rats. Methods: 24 Sprague-Dawley rats underwent UUO and were randomly divided into two groups: UUO group (n=12) and Lef-treated group (=12). Then they respectively received vehicle or Lef(10 mg/kg·d-1 by daily gastric gavage)during the 14 days following surgery. Additional 12 rats received sham operation. Six rats of each group were killed respectively in 7 and 14days after surgery. Immunohistochemistry was performed on renal tissue for proliferating cell nuclear antigen(PCNA),α-smooth muscle actin(α-SMA),which was cytosheletal marker of Myoibroblast(Myo) and collagenⅠ,Ⅲ. Histological changes were also observed by HE and Masson stain. Result: In comparison with the UUO group, α-smooth muscle actin, PCNA and collagenⅠ,Ⅲ deposition were all significantly reduced by Lef treatment. Conclusion: Lef can prevent renal interstitial fibrosis process in UUO rats by reducing interstitial Myo infiltration and collagenⅠ,Ⅲ deposition . Lef may be used to slow the progression of chronic renal disease.
【Fund】: 广西科学研究与技术开发应用基础研究专项项目(桂科基01560022)
【CateGory Index】: R692
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