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A bioinformatics analysis on 3-hydroxy-3-methylglutaryle-CoA reductase, a key enzyme in plant isoprenoid biosynthesis

LI Rong, WANG Zhe-zhi ( College of Life Sciences, Shaanxi Normal University, Xi’an 710062, China )  
In the present study,3-hydroxy-3-methylglutaryl-CoA reductase from rubber,tobacco,capsicum and andrographis,which were registered in GenBank,were analyzed and predicted by the tools of bioinformatics in the following aspects:the composition of nuclei acid sequences and amino acid sequences,signal peptide,transmembrane topological structure,hydrophobicity or hydrophilicity,secondary and tertiary structure of protein, molecular phylogenetic evolution and so on. The results are as follows:the full-length gene of HMGR contains an opening reading frame,5′-untranstrated region and 3′-untranstrated region;HMGR is a hydrophilic and transmembrane protein which lack of signal peptide;the amino acid sequences of HMGR include two functional HMG-CoA binding motifs and two functional NADPH binding motifs;the main motif of predicted secondary structure of HMGR are alpha helix and random coil,beta turn and extended strand are spreaded in the whole secondary structure of protein;the predicted tertiary structure of functional domain of HMGR includes the helical N-domain,S-domain and L-domain.
【Fund】: 国家“十五”科技攻关项目(2004BA721A35)~~
【CateGory Index】: Q946
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