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《Guihaia》 2012-01
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Studies on isolation、purification、structural identification and its antitumor activity of polysaccharides from Momordica grosvenori swingle’s root

YAN Xiao-Jie1,2,LU Feng-Lai1,CHEN Huan-Ying1,2,LI Dian-Peng1(1.Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization,Guangxi Institute of Botany,Guilin 541006,China;2.College of life science,Guangxi Normal University,Guilin 541004,China)  
Polysaccharide(CPS) of Momordica grosvenori swingle’s roots was extracted by water extracting-alcohol precipitating method,and then was pufified by DEAE-52 cellulose.Their compositions were analyzed by paper chromatography and high performance liquid chromatography(HPLC) .And the effect of CPS on H22 subcutaneous planting of mice was studied.Results:CPS was isolated into five fractionates by DEAE-52 cellulose column chromatography,its simple sugars composition included glucose,arabillose and xylose.Compared with model group,each dose group had no significant functions in suppressing tumor growth(inhibition rate50%) ;Besides,Compared with model group,each dose group had improved influence on the index of thymus(P0.01) ,but had reduced influence on the index of spleen(P0.01) .
【Fund】: 中国科学院“西部之光”人才培养计划专项(科发人教字[2009]24号);; 药用资源化学与药物分子工程教育部重点实验室资助(桂科能07109001-13);; 广西植物研究所基本业务费(桂科植1003)~~
【CateGory Index】: S668.9;Q946.3
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