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《China Medicine and Pharmacy》 2011-16
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Clinical observation of adjuvant chemotherapy of postoperative gastric cancer by compound Matrine injection combined with DFC chemotherapy regimen

LU Binbin WANG Zhaoxia WANG Juan LI Juan WANG Jirong WANG Keming Department of Oncology,the Second Affiliated Hospital of Nanjing Medical University,Nanjing 210011,China  
Objective To observe and compare the toxicity of compound Matrine injection in combination with DCF regimen(doce taxel+cisplatin+fluorouracil) and DCF regimen in the adjuvant chemotherapy of patients with postoperative gastric cancer. Methods 40 patients with postoperative Ⅱ-Ⅲ stage gastric cancer diagnosed pathologically were divided into compound Matrine injection in combination with DCF regimen group(study group) 20 cases and DCF regimen group(control group) 20 cases.Each patient was given 6 cycles and the toxicity was then evaluated. Results 25 cases could be evaluated in study group and 24 cases could be evaluated in control group. The difference of incidence rates of leucopenia,gastrointestinal,hepatic function and anergy between the two groups was significant(P 0.05) . Conclusion Compound Matrine injection can reduce toxicity in study group significantly while enhancing patients’ tolerance to chemotherapy.
【Fund】: 南京医科大学重点项目(2009NJMUZ21)
【CateGory Index】: R735.2
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