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《China Medicine and Pharmacy》 2013-07
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Effect of fleabane injection on the expression of insulin-like growth factor-1 in hippocampus after cerebral ischemic reperfusion in rats

LAN Xiaolei 1 LIU Aihua 2 WANG Suping 3 XU Xinying 2 1.Department of Neurosurgery,Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,China; 2.Department of Medicine, People's Hospital of Jiyang County, Jiyang 2501400; 3. Department of Rehabilitation, the Third Municipal Hospital of Qingdao City,Qingdao 266043, China  
Objective To study the neuroprotective effect of fleabane injection on cerebral ischemic reperfusion injury in rats. Methods Total of 24 adult healthy male Wistar rats were used to established cerebral ischemia 2h and reperfusion 48h expression models by inserting a thread intraluminally from the left external-internal carotid artery, and then treated by injecting fleabane injection intraperitoneally (3.6 mg/kg). The morphology of neuron was observed by HE stain and the neuronal apoptosis was detected by TUNEL assay, while the expression of insulin-like growth factor-1(IGF-1) in hippocampus were determined by immunohistochemical technique. Results After treated with fleabane injection, the expression of IGF-1 and the number of neurons in hippocampus increased with the cognitive ability improving significantly. Conclusion Fleabane injection might improve the memory ability by inhibiting neuronal apoptosis and up-regulating the expression of IGF-1.
【CateGory Index】: R285.5
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【Citations】
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【Co-citations】
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1 Yan Yun-zhen(Chongqing Xiushan Chineses Medical Hospital,Xiushan 409900);Effect of breviscapine on cerebral ischemia-reperfusion injury[J];Sichuan Journal of Physiological Sciences;2008-03
2 Deshan Liu, Weiwei Lin, Wei Gao, Ping Chang, Wei Li Department of Traditional Chinese Medicine, Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China;Effect of Yiqi Bushen prescription on hippocampal neuronal apoptosis in diabetic rats[J];中国神经再生研究(英文版);2011-21
3 DU Xue-mei1,HUANG Zheng-zheng21(Department of Neurology,The Third People's Hospital of Chongqing,Chongqing 400016,China)2(Department of the Fourth Internal Medicine,The Integrated Chinese-Western Medicine Hospital of Sichuan,Chengdu 610000,China);Breviscapine prevents deep venous thrombosis after ischemic stroke surgery[J];Medical Journal of West China;2012-06
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4 Li Xiao-ling,Zhou Zhong-guang,Wang Zhi-guoAuthor's address:Qiqihar Medical College,Qiqihar 161042,China;The experiment study of naojian inhalant effection on 5-HT and MAO of AD rat[J];Acta Chinese Medicine and Pharmacology;2005-03
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