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Preventive Effects of Nimodipine on Cerebral Injury Induced by Carbon Monoxide Intoxication in Mice

YANG Jun qing,ZHOU Qi xin (Department of Biochemical Pharmacology,Chongqing University of Medical Sciences,Chongqing 400016 China)  
In order to study the effects of Nimodipine on delayed cerebral injury in mice induced by sub acute carbon monoxide(CO)intoxication,mice were exposed to CO(100 ml/kg,ip)once a day,successively for 7 days.Each time,Nimodipine was administrated 30 min beforehand.Following items were investigated:mortality rate of mice,changes of learning and memory in passive avoidance test,the pathomorphologic observation of brain tissue,and changes of monoamine oxide(MAO) B activities in cerebral tissue.Results showed that pre administration of Nimodipine significantly decreased the mortality rate of mice,almost reversed the impairment of learning and memory function,prevented the delayed cell death in hippocampal neurons and blunted the rising of MAO B activity from sub acute CO poisoning in mice.These results suggested that pre treatment of Nimodipine could markedly prevent the mice from delayed encephalopathy after CO poisoning.
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