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《Industrial Health and Occupational Diseases》 2005-02
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Effects of Cerium on Proportion of Internal Organs of Rats and Anti-oxidation Ability in Liver and Kidney

GONG Ju-fang *,ZHANG Zi-gui *,SHEN Xiu-ying *, XU Xiao-lu,CAI Rong-gang * ( * College of Chemistry & Life Sciences,Zhejiang Normal University,Jinhua 321004 China)  
Objective To study some biological effects and mechanisms of cerium on male and female Spraque-Dawley(SD)rats.Methods The rats were fed with cerium-containing solution for a long term,instead distilled water was fed for controls for 5 months.Then the rats were sacrificed to get the ratio of organs to body weight by weighing;the activities of SOD and the contents of MDA in the liver and kidney were detected.Results Compared with the control group,the ratios of lungs to body weight of male rats in three dosages groups increased obviously,(4.1±0.8),(3.7±0.4),and(4.3±1.5)mg/g respectively;while in female rats obvious increase was found only in low and middle dasages groups(P0.05).The ratio of liver to body weight of low dose female rats increased remarkably(33.2±6.3)mg/g.Different effects of cerium on target organs of male and female rats were observed.Cerium could significantly reduce the activities of SOD(P0.05)in liver of three dosages groups,( 3 034.6±566.6),( 3 050.5±456.3),and( 3 083.4±560.3)U/ml respectively.The activities of SOD in kidney of middle and high dosages groups were down obviously(P0.05),while the levels of MDA in liver and kidney had no obvious change.Conclusions Cerium has toxic effects on liver and lung of rats,and could decrease the antioxidation ability of the liver and kidney.
【Fund】: 浙江省教育厅资助项目 ( 2 0 0 2 0 85 3 );; 浙江省大型仪器分析测试基金资助项目 ( 0 2 0 82 )
【CateGory Index】: R114
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