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《Industrial Health and Occupational Diseases》 2007-05
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Experimental Study on Antagonization of Lead Toxicity by Zinc and Chinese Herbal Preparation

LI Chao-gan,ZHANG Shu-qiu,LIANG Yue-xiu,LIU Yan,HUANG Qiu-yan,LIANG Wei-jiang,CHOU Guo-quan(Youjiang Medical College for Nationalities,Baise Guangxi 533000 China)  
Objective To study the effect of zinc and Chinese herbal preparation on biochemical indices in lead exposed mice.Methods 60 male mice were divided randomly and equally into five groups,namely treatment group 1,treatment group 2,treatment group 3,the positive control group and the negative control group.Mice in former 4 groups were exposed to lead by peritoneally injecting 2 g/L lead acetate water solution once a day successively for 35 days.Mice in the negative control group were peritoneally injected with normal saline at the same volume.After being exposed for 14 days,the treatment began.Mice in the treatment group 1 were given zinc only.Mice in the treatment group 2 were given zinc and Chinese herbal preparation.Mice in the treatment group 3 were given Chinese herbal preparation only.Mice in the positive control group and negative group were given equal amount of distilled water.All these were done once a day till to the end of experiment.Body weight and Hb of each mouse were measured before and after the experiment.After the experiment was ended,levels of lead,zinc,calcium,urea and ALT in serum,levels of calcium,NO,activity of TchE and activity of GSH-Px in brain tissues,clearance of brain homogenate and liver homogenate to O·2 were determined.Results Serum lead Levels in treatment groups 1,2 and 3,and the positive and negative control groups were(0.070 9±0.012 9),(0.052 2±0.051 8),(0.054 7±0.017 5),(0.119 0±0.027 2),(0.010 3±0.002 6)mol/L,in which the content in the positive control group was obviously higher than those of other groups.Serum zinc levels were(0.096 8±0.038 5),(0.084 9±0.010 3),(0.091 1±0.031 8),(0.023 5±0.037 2),(0.061 8±0.003 1)mol/L,in which the content in the positive control group was obviously lower than those in treatment groups 2 and 3.Brain NO were(13.66±3.43),(12.85±4.70),(15.80±4.40),(23.03±7.80),(12.59±3.90)μmol/L,in which the content in the positive control group was obviously higher than those of other groups.Brain calcium levels were(1.9± 0.1),(1.0 ±0.2),(1.1±0.2),(0.6±0.2),(2.2±0.3)mol/L,in which the content of the positive control group was obviously lower than those of other groups.Brain TchE levels were(2.67±0.69),(5.95±1.59),(6.08±1.65),(6.21±0.28),(2.86±0.99)U/mg protein,the contents in the negative control group and treatment group 1 were obviously lower than those of other groups.As to other indexes such as serum ALT,urea,calcium content,Hb,and clearance of O·2,significant differences existed among the positive control group and the negative control group,and all treatment groups.Conclusion There is a significant promotion effect to recover some biochemical indices of lead exposed mice by zinc and Chinese herbal preparation.
【CateGory Index】: R96
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