Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Industrial Health and Occupational Diseases》 2007-05
Add to Favorite Get Latest Update

Experimental Study on Antagonization of Lead Toxicity by Zinc and Chinese Herbal Preparation

LI Chao-gan,ZHANG Shu-qiu,LIANG Yue-xiu,LIU Yan,HUANG Qiu-yan,LIANG Wei-jiang,CHOU Guo-quan(Youjiang Medical College for Nationalities,Baise Guangxi 533000 China)  
Objective To study the effect of zinc and Chinese herbal preparation on biochemical indices in lead exposed mice.Methods 60 male mice were divided randomly and equally into five groups,namely treatment group 1,treatment group 2,treatment group 3,the positive control group and the negative control group.Mice in former 4 groups were exposed to lead by peritoneally injecting 2 g/L lead acetate water solution once a day successively for 35 days.Mice in the negative control group were peritoneally injected with normal saline at the same volume.After being exposed for 14 days,the treatment began.Mice in the treatment group 1 were given zinc only.Mice in the treatment group 2 were given zinc and Chinese herbal preparation.Mice in the treatment group 3 were given Chinese herbal preparation only.Mice in the positive control group and negative group were given equal amount of distilled water.All these were done once a day till to the end of experiment.Body weight and Hb of each mouse were measured before and after the experiment.After the experiment was ended,levels of lead,zinc,calcium,urea and ALT in serum,levels of calcium,NO,activity of TchE and activity of GSH-Px in brain tissues,clearance of brain homogenate and liver homogenate to O·2 were determined.Results Serum lead Levels in treatment groups 1,2 and 3,and the positive and negative control groups were(0.070 9±0.012 9),(0.052 2±0.051 8),(0.054 7±0.017 5),(0.119 0±0.027 2),(0.010 3±0.002 6)mol/L,in which the content in the positive control group was obviously higher than those of other groups.Serum zinc levels were(0.096 8±0.038 5),(0.084 9±0.010 3),(0.091 1±0.031 8),(0.023 5±0.037 2),(0.061 8±0.003 1)mol/L,in which the content in the positive control group was obviously lower than those in treatment groups 2 and 3.Brain NO were(13.66±3.43),(12.85±4.70),(15.80±4.40),(23.03±7.80),(12.59±3.90)μmol/L,in which the content in the positive control group was obviously higher than those of other groups.Brain calcium levels were(1.9± 0.1),(1.0 ±0.2),(1.1±0.2),(0.6±0.2),(2.2±0.3)mol/L,in which the content of the positive control group was obviously lower than those of other groups.Brain TchE levels were(2.67±0.69),(5.95±1.59),(6.08±1.65),(6.21±0.28),(2.86±0.99)U/mg protein,the contents in the negative control group and treatment group 1 were obviously lower than those of other groups.As to other indexes such as serum ALT,urea,calcium content,Hb,and clearance of O·2,significant differences existed among the positive control group and the negative control group,and all treatment groups.Conclusion There is a significant promotion effect to recover some biochemical indices of lead exposed mice by zinc and Chinese herbal preparation.
【CateGory Index】: R96
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 4 Hits
1 Li Shuhua et al.MuDanjiang Medicine College, Mudanjiang 157011;An Experimental Study on the effect of SNPon the Chang of NO、SOD、MDA in lead-treated mouse brain[J];Journal of Mudanjiang Medical College;2004-05
2 XIAO Hua Shan, HE Wen Jin, FU Wen Qing, CAO Hong Yun, FAN Zi Nan( Biotechnology College of Fujian Normal University ,Fuzhou 350007,China).;A Spectrophotometer Method Testing Oxygen Radicals .[J];PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS;1999-02
3 ZHANG Hong - zhong,SONG Mei (Zhuhai Maternal and Child Health's Hospital,Zhuhai 519001,China);Investigation on Variety of Blood Zinc,Copper,Iron,Calcium Levels in Children with Lead Poisoning[J];Journal of Applied Clinical Pediatrics;2005-05
4 WU Yuntang,CHE Suping,SUN Zhong,et al.School of Public Health,Tianjin Medical University(Tianjin 300070,China);Changes of serum nitric oxide and protection of zinc and selenium in diabetic rats[J];China Public Health;2005-02
【Secondary Citations】
Chinese Journal Full-text Database 5 Hits
1 Li Shuhua,Yuan Hongwei,Gu Hongmei,et al.Mudanjiang Medical College,Mudanjiang 157011;Chang of NO、SOD、MDA in lead-treated rat brain and their correlation[J];Chinese General Practice;2003-11
2 Xiao Huashan Fu Wenqing (Department of Biolody, Fujian Normal University)Zhao Baolu Yang Fajun Xin Wenjuan (Institute of Biophysics, Academia Sinica);STUDIES ON GENERATION AND SCAVENGING OF OXYGEN RADICALS IN THE SYSTEM OF AMMONIUM PERSULFATE -N,N,N',N'- TETRAMETHYL ETHYLENEDIAMINE[J];Acta Biophysica Sinica;1992-02
3 Wang Yanyan, Wang Yijun, Wang Xiao, et al/General Hospital of Chinese PLA Nanjing Commond, Nanjing 210002;Relationship between Nitric Oxide in Serum and Microangiopathy in Diabetes Mellitus[J];CHINESE JOURNAL OF MICROCIRCULATION;1999-01
4 LI Ming xia, Abulaiti, WU Ning (Department of Neonatology, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China);The effect of low level prenatal lead exposure on neonatal calcium phosphorus metabolism and hematopoietic system[J];Journal of Xinjiang Medical University;2003-05
5 WANG Ai-Guo, LUO Guang-Hua (Soutch China Institute of Botany, Academia Sinica, Guangzhou 510650);Quantitative Relation between the Reaction of Hydroxylamine and Superoxide Anion Radicals in Plants[J];Plant Physiology Communications;1990-06
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved