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《Industrial Health and Occupational Diseases》 2007-06
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Significance of Combinatory Detection of Hydrothorax ProgastrinReleasing Peptide and Carcino-embryonic Antigen in Diagnosisof Lung Cancer Complicated with Malignant Pleural Effusion

LIU Yun-qiu,LAN Xuan,GAO Wei-dong,ZOU Ji-min,GENG He-mei,TANG Xiao-xia(Affiliated Kailuan Hospital,North China Coal Medical College,Tangshan 063000 China)  
Objective To study the clinical significance of combinatory detection and detection alone of the hydrothorax progastrin releasing peptide(ProGRP)and carcino-embryonic antigen(CEA)in diagnosis of malignant pleural effusion induced by lung cancer.Methods By the ELISA(enzyme linked immunosorbnent assay),the levels of hydrothorax ProGRP and CEA were detected in 33 cases of malignant pleural effusion induced by SCLC(small cell lung cancer),36 malignant pleural effusion induced by NSCLC(non-small-cell lung cancer),and 32 benign hydrothorax(the benign group),respectively.The significance of combinatory detection and detection alone of the hydrothorax ProGRP and CEA in the diagnosis of the malignant pleural effusion was compared.Results The positive rates of hydrothorax ProGRP in the SCLC group,the NSCLC group and the benign group were 90.91%,2.78% and 3.00 % respectively;the positive rates of hydrothorax CEA in these three groups were 45.45%,83.33%,and 12.00 % respectively.The Youden indexes of the hydrothorax ProGRP alone,the CEA alone,the ProGRP+CEA combinatory(according to sequence tests)and the ProGRP+CEA combinatory(in parallel tests)in diagnosis of the malignant pleural effusion induced by the SCLC were 0.877 8,0.048 3,0.483 9 and 0.751 9 respectively.The Youden indexes in diagnosis of the malignant pleural effusion induced by the NSCLC were-0.003 5,0.708 3,0.135 4 and 0.673 6 respectively.The Youden indexes in diagnosis of the malignant pleural effusion induced by lung cancer were 0.251 2,0.402 2,0.307 0 and 0.711 1 respectively.Conclusions The hydrothorax ProGRP and CEA are preferable biomarkers of cancer in diagnosis of the malignant pleural effusion induced by the SCLC and NSCLC.Combinatory detection of hydrothorax ProGRP+CEA in parallel tests is highly significant in the diagnosis of the malignant pleural effusion induced by lung cancer.
【CateGory Index】: R734.2
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