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《Industrial Health and Occupational Diseases》 2014-06
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Expression of matrix metalloproteinase-9 in rats with chlorine-induced acute lung injury

JIANG Jun-kang;QIN Jiang-chun;XU Pei-pei;QU Jian-hua;WANG Chun;CHEN Gang;School of Public Health,Nantong University;  
Objective To explore the changes of gene and protein matrix metalloproteinase-9(MMP-9)in rats exposed to different concentrations of chlorine.Methods Forty male SD rats were randomly divided into one control group and four experiment groups inhaled different concentration of chlorine for 10 minutes each,and were sacrificed at time point of 6hs after cessation of exposure.The concentration of MMP-9in the bronchoalveolar lavage fluid(BALF)by ELISA,and the expression of MMP-9mRNA in lung tissue by reverse transcription-polymerase chain reaction(RT-PCR)were analyzed,while the detection of the content of PaO2,wet/dry weight ratio of lung tissue(W/D)and the pathologic observation were taken respectively.Results The expression of MMP-9in BALF and lung tissue was increased significantly in all experiment groups as compared with the control group(P0.05),and gradually increased with the concentration of chlorine rises(P0.05).Conclusions MMP-9may play an important role in progression of acute lung injury induced by chlorine.
【CateGory Index】: R135.1
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