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《Industrial Health and Occupational Diseases》 2014-06
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Expression of matrix metalloproteinase-9 in rats with chlorine-induced acute lung injury

JIANG Jun-kang;QIN Jiang-chun;XU Pei-pei;QU Jian-hua;WANG Chun;CHEN Gang;School of Public Health,Nantong University;  
Objective To explore the changes of gene and protein matrix metalloproteinase-9(MMP-9)in rats exposed to different concentrations of chlorine.Methods Forty male SD rats were randomly divided into one control group and four experiment groups inhaled different concentration of chlorine for 10 minutes each,and were sacrificed at time point of 6hs after cessation of exposure.The concentration of MMP-9in the bronchoalveolar lavage fluid(BALF)by ELISA,and the expression of MMP-9mRNA in lung tissue by reverse transcription-polymerase chain reaction(RT-PCR)were analyzed,while the detection of the content of PaO2,wet/dry weight ratio of lung tissue(W/D)and the pathologic observation were taken respectively.Results The expression of MMP-9in BALF and lung tissue was increased significantly in all experiment groups as compared with the control group(P0.05),and gradually increased with the concentration of chlorine rises(P0.05).Conclusions MMP-9may play an important role in progression of acute lung injury induced by chlorine.
【CateGory Index】: R135.1
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 WU Shan 1,JIANG Zhi xue 2,SUN Ming 2,SHENG Yan liang 2 ,ZHOU Yi 1 (1.The First Affiliated Hospital of Chongqing Medical University,Chongqing 400000,China;2.Jiamusi University,Jiamusi,China);Changes of the plasma levels of E-selectin and endothelin-1 in lung edema rats caused by chlorine[J];Chinese Journal of Industrial Medicine;2003-05
2 HE Dai-kun,SHEN Jie(Emergency & Intensive Care Centre for Chemical Accident of Fundan University,Shanghai 200540,China);Research Progress on Lung Injury Caused by Phosgene Inhalation[J];Occupational Health and Emergency Rescue;2007-02
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 WEI Yujie,WANG Lei,JING Shen,CHENG Weipeng,LI Mozhen.Intensive Care Unite,General Hospital of Wanbei Coal-Electric Group,Suzhou 234000,China;Efficac comparison of non-invasive and invasive positive pressure ventilation in treatment of acute respiratory distress syndrome caused by phosgene poisoning[J];Clinical Medicine;2011-11
2 ZHANG Lin SHEN Jie HUANG Wenbin HE Daikun Emergency & Intensive Care Centre for Chemical Accident of Jinshan Hospital,Fudan University,Shanghai 200540,China;Expression and Effect of MMP-9 and TNF-α in Rats with Phosgene-Induced Acute Lung Injury[J];Chinese Journal of Clinical Medicine;2010-04
3 SHEN Jie ZHANG Lin He Dai-kun HUANG Wen-bin (Emergency & Intensive Care Center for Chemical Accident,Jinshan Hospital Affiliated to Fudan University,Shanghai 200540,China);Expression of MMP-9 in Rats with Phosgene-induced Acute Lung Injury[J];Journal of Environmental & Occupational Medicine;2008-03
4 ZHANG Lin1,REN Tian-cheng2,SHEN Jie1(1.Emergency & Intensive Care Centre for Chemical Accident of Jinshan Hospital Affiliated to Fudan University,Shanghai 200540,China;2.Key Laboratory of Anesthesiology of Jiangsu Province,Xuzhou,Jiangsu 221002,China);Role of Matrix Metalloproteinase-9 in Phosgene-induced Lung Injury[J];Journal of Environmental & Occupational Medicine;2009-02
5 LIU Liangqing;YUE Maoxing;ZHENG Jiangang;Department of Radiology,Affiliated Wujin People's Hospital of Jiangsu University;;Comparative Analysis Between Clinical Manifestations and Chest Image Performance in Moderate to Severe Chlorine Poisoning[J];Journal of Clinical Radiology;2013-11
6 WANG Guangyang;REN Xianzhi;Nanjing University of Chinese Medicine;;Danshao Granule on MMP-2 and MMP-9 of Rat Mesangial Cells in Vitro[J];Journal of Liaoning University of Traditional Chinese Medicine;2014-08
7 REN Cui-rong,ZHANG Lin-yu,WEI Nan,YAN Lin-ru;Effect of irrtative poison on nasopharynx at long term and low level exposure[J];Chinese Journal of Industrial Medicine;2011-05
8 ;Expression changes of Claudin-3 and Occludin in lungs of rats exposed to chlorine[J];Chinese Journal of Industrial Medicine;2014-02
9 TAO Dong-ying;NI Jing-jing;REN Dian-huan;YU Ji-mian;ZHANG Xiu-juan;WANG Yong;Department of Human Morphology,Ningbo College of Health Science;;The protective effects of Jidesheng Sheyao pian on lung ischemiareperfusion injury in rats[J];Chinese Journal of Clinical Pharmacology and Therapeutics;2013-11
10 Su Weiguo;Wang Pingli;Niu Xihua;Nanfang Hospital of Southern Medical University;Dept of Burns,The First People's Hospital of Zhengzhou;He'nan Medical College;;Therapeutic effect of doxycycline in patients on lung fuction following severe inhalation injury[J];Acta Universitatis Medicinalis Anhui;2013-12
【Secondary Citations】
Chinese Journal Full-text Database 7 Hits
1 LI Wen-li, HAI Chun-xu, LIU Rui, LIANG Xin, ZHANG Xiao-di, WANG Peng. Department of Toxicology, Fourth Military Medical University, Xi'an 710033, China;The oxidant injury induced by phosgene of lung in mice[J];Chinese Journal of Disease Control and Prevention;2004-06
2 ZHU Guangfa,MIN Jun,ZHANG Guoqing,et al.Department of Respiratory Medicine,Shanghai First Peoples Hospital,Shanghai 200080,China;Pulmonary surfactant in the prevention and treatment of acute respiratory distress syndrome in rats[J];Journal of Emergenoy Medicine;2003-01
3 WANG Peng,LIANG Xin,HAI Chun-xu.Department of Toxicology,Faculty of Preventive Medicine,the Fourth Military Medical University(Xi'an 710032,china);Study on therapeutical effect of carbonic acid buffer on rats exposed to phosgene and its mechanisms of oxidation[J];China Public Health;2004-12
4 LI Wen-li,HAI Chun-xu,QIN Xu-jun LIANG Xin,Chen Hong-li.Department of Toxicology,The Fourth Military Medical University,Xi'an 710033,China;Effect of phosgene on apoptosis of alveolar type Ⅱ cells and vascular endothelial growth factor in exposed mice[J];Chinese Journal of Industrial Hygiene and Occupational Diseases;2004-03
5 WANG Ling,XU Li-Xian,HAI Chun-Xu,QIN Xu-Jun, 150 hospital of PLA,Luoyang, 471031,China;Observation on the protective effect of hyperoxia solution on the acute lung injury caused by phosgene poisoning[J];Chinese Journal of Industrial Hygiene and Occupational Diseases;2005-01
6 Guan Jian,Jin Dadi,Jin Lijuan.Department of Orthopedics,Nanfang Hospital of the First Military Medical University,Guangzhou 510515;Experimental study on pulmonary apoptosis in rats early after polytrauma combined with shock[J];CHINESE CRITICAL CARE MEDICINE;1998-08
7 WANG Zhao xiong, LI Si hui(Shanghai Institute of Occupational Medicine for Chemical Industry, Shanghai 200041, China);STUDY ON CLINICAL FEATURES OF ACUTE PHOSGENE POISONING[J];Occupational Health and Emergency Rescue;2002-02
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