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《Journl of Guiyang Medical College》 1986-03
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THE EFFECTS OF TOTAL ALKALOIDS OF SOPHORA FLAVESCENS ON THE CORONARY ARTERY BLOOD FLOW

Cha Li Res Dep of Geriatrics of Province Guizhou  
Total alkaloids of Sophora Flavescens (AF) are isolated from Sophora Flavescens Root and their effect on the coronary artery blood flow are investigated. AF given intraveuosly (25mg/kg) to dogs treated with pituitrin are markedly increased the coronary artery blood flow (P0.001), and markedly decreased the coronary artery resistance, while heart rate and arterial blood pressure were without significant change. According to Langendroff's model, AF infused into isolated rabbit heart. It was shown that also markedly inereasei the coronary artery blood flow, but did not significantly change neither myoeardial contractibility nor heart rate. On the model of myocardial ischemia of rats induced by systemically injecting of high concentration of pituitrin in the AF treated group the drop of S-T segment in ECG are significantly less than the control. The function of the ischemic myocardia induced by pituitrin was improved, and arrhythmia was prevented.
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