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《Journl of Guiyang Medical College》 1993-04
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Toxic Effect of Trace Element Cadmium on the Mouse Testes

Luo Zhengguo, el al Department of Histology, and E nibryoloy Guiyang Medical College  
Sixty mice divided into 4 groups, 3 experimental and 1 control, were injected subcutaneously once a week with cadmium (Cd) aqueous solution of 1.00mg/kg, 0.50mg/kg and 0.25mg/kg as higher, median and lower doses in the experimental groups, respectively, for one year. part of the experimental animals were observed after the injection was cut off for half a year. The testes and epididymides were observed with routine histological methods at the light and electron microscopic leves. In the seminiferours tubules, abnormal changes were demonstrated as sparse epithelia with a state of chaos, vacuolization in spermatogonia, appearing of giant and multinucleatted cells,or various amounts of acidophil material, and absence of spermatogenic cell with Sertoli cells or only the basement membrane being remai ned. The mitochondria accumulated, swelled or vacuolized in some spermato cytes and spermatogonia. Histochemically we observed with methods of alkaline phosphatase, acid phosphatase and periodic acid schiff reaction, and analysed the content of DNA by a inicrospectrophotometer. The mechanism. of the toxic effect of Cd to testes and epididymides was discussed, we considered that even in a very low dosage Cd will still be able to damage the animal or human being.
【Fund】: 国家自然科学基金
【CateGory Index】: R321. 1
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