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《Journal of Guiyang Medical College》 2008-05
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The Anticancer Activity of Compounds in Lipophilic Fraction of Daucus carota

JING Jing, YANG Ruolin, LU Yang(Medical College, Shanghai Jiao Tong University, Shanghai 200237, China)  
Objective:To search for compound(s) with anticancer activity from lipophilic fraction of Daucus carota. Methods: Extraction from D. carota was obtained with several chemical means such as solvent extraction, thin-layer chromatography, column chromatography, and high performance liquid chromatogram. The structural identification was completed by the determination of the chemical and phasical constants, 1H-NMR, 13C-NMR and ultraviolet spectrum. Results: Three constituents, β-sitosterol, laserine and epilaserine, were isolated from the lipophilic fraction of D. carota. Among the 3 constituents, epilaserine showed significantly inhibitory effect on leukemia cell, HL-60, and laserine and epilaserine were isolated from D. carota for the first time. Conclusion: D. carota has anticancer constituent, epilaserine, in its lipophilic fraction.
【CateGory Index】: R284
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