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《Journal of Guiyang Medical College》 2008-06
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The Relationship between Hair Trace Elements and Arsenic Poisoning in Arsenism Patient Caused by Coal-burning

ZHANG Aihua1,CHEN Lang1,ZHANG Ran1,LI Jun1,ZHAO Zhuandi1,ZOU Zhilin1 HUANG Xiaoxin2,ZHANG Bixia2(1.Department of Toxicology,School of Public Health,Guiyang Medical College,Guiyang 550004,Guizhou,China;2.The 44th Hospital of PLA ,Guiyang 550009,Guizhou,China)  
Objective:To explore the relationship between arsenism and trace elements in hair of arsenism patients caused by coal-burning,so as to provide bases for theoretical study,diagnosis,and intervention of arsenism. Methods:For 107 arsenism patients and 30 healthy people (as control),the concentrations of Cu,Mn,Zn,Fe,Ca,and Mg in hair were measured with Flame Atomic Absorption Spectrometry,and the concentrations of As,and Se were tested with Flame Atomic Fluorescence Spectrometry. The data were analyzed statistically. Results:The concentrations of Se,Zn,Ca and Mg were lower and the concentrations of Cu,Fe,Mn and As were higher significantly in the hair of patients than those of control group; There was a trend that concentrations of Se,Zn,Cu,Fe and Mn in hair of arsenism patients decreased or increased along with the aggravating of the disease. Conclusions:Arsenic can effect the balance of trace elements in human's body and the unbalance of trace elements may be one of the important mechanisms of arsenism. To monitor and to supplement some trace elements with known effects such as Zn and Se will be helpful for diagnosis and intervention of arsenism.
【Fund】: 国家自然科学基金资助项目(30460123);; 贵州省优秀人才省长专项基金(黔省专合字380号);; 贵州省重大专项基金(黔科合重大专项字6016号)
【CateGory Index】: R599
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