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《Journal of Guiyang Medical College》 2009-05
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Changes of Malonalldehyde and Hydroxyproline Contents,Xanthine Oxidase and Total Superoxide Dismutase Activities in Pathological Scars

KONG Yusu,LI Weiren,DU Jiao,LU Jiaxiang,WANG Wei(The Affiliated Hospital of Guiyang Medical College,Guiyang 550004,Guizhou,China)  
Objective:To observe the changes of malondialdehyde (MDA),hydroxyproline (Hyp) contents,and xanthine oxidase (XOD),and total superoxide dismutase (T-SOD) activities in pathological scars,discuss the effect of free radicals in the excessive proliferation of scars. Methods: In July 2006 ~ August 2007 during the surgical resection,specimens of 35 cases including hypertrophic scars (10 cases),keloids (10 cases),mature scars specimens (6 cases)and normal skin specimens (9 cases)were collected. Specimens were washed,homogenized,centrifuged and the supernatant were examined with chemistry colorimetric assay. Results: MDA content,Hyp content,and activities of XOD,and T-SOD were significantly higher in hypertrophic scars and keloids than those in normal skin (P0.05) and in mature scars (P0.05);The differences of those data between mature scar and normal skin,and between hypertrophic scars and keloids were not statistically significant (P0.05,P0.05);Conclusion: The levels of free radicals are high in pathological scars,which might relate to collagen deposition and cicatrix hyperplasia.
【Fund】: 贵州省科技厅基金项目[黔科合J字《2006》2062号]
【CateGory Index】: R622.9
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