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《Journal of Guiyang Medical College》 2009-05
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A Study on the Auxiliary Protective Effect of Ciyi Compound against Radiation Caused Injury

WU Xiaoli1,WU Mingjiang1,CHEN Xiufen1,ZHANG Yali2,JIANG Zhaohui1(1. Guiyang College of Traditional Chinese Medicine,Guiyang 550002,Guizhou,China;2. The First Affiliated Hospital of Guiyang College of Traditional Chinese Medicine,Guiyang 550002,Guizhou,China)  
Objective:To study the auxiliary protective effect of Ciyi compound. against radiation hazards.Methods: Kunming mice were given with Ciyi compound orally for 14 days before irradiated by Co60γ-ray (2~7 Gy) one-time systemically. Ciyi compound was given to mice for different days (3~14 days) after the radiation again,and on different days of the continous Ciyi treatment,peripheral blood white blood cell counts (WBC),bone marrow karyote cell counts (BMKC),bone marrow cell micronucleus rates (BMMR),blood superoxide dismutase (SOD) activity,and antibody cumulation values of serum hemolysin (ACVH) were detected. Results: WBC,BMKC,SOD activity,and ACVH were significantly higher in mice treated with high-dose and middle-dose of Ciyi compound (P0.05,P0.01) than those in control group,while BMMR in high-dose of Ciyi compound treated nice was obviously lower than that in controls (P0.01). Conclusion: Ciyi compound has auxiliarily protective effect against radiation hazards,and a dose dependence of protection existences in a dosage range.
【Fund】: 贵州省中药现代化专项科技项目[黔科合中药专字(2003)73号]
【CateGory Index】: R285.5
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