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《Journal of Guiyang Medical College》 2011-03
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Expression of Gastrin Gene in Human Gastric Cancer Tissues and Metastatic Lymphatic Tissues

ZHAO Yan1,XIE Yuan1,WANG Wenling2,WANG Su1,CHEN Xian1,ZHOU Jianjiang1,2 (1.The Key Laboratory of Molecular Biology,Guiyang Medical College,Guiyang 550004,Guizhou,China;2.Department of Internal Medicine,Cancer Hospital of Guizhou Province,Guiyang 550004,Guizhou,China)  
Objective:To explore the relationship of expression levels of gastrin gene in matched human gastric carcinoma,lymph tissue and adjacent non-neoplastic mucosa of gastric cancer patients with development and progression of the disease.Methods:Total RNA was extracted and purified from gastric carcinoma tissues,lymph tissue and adjacent non-neoplastic mucosa of patients,and gastrin mRNA levels(mRNAL) were determined with Taqman real-time quantitative PCR.Results:The mRNAL in gastric carcinoma tissues was lower than that in adjacent non-neoplastic mucosa(with ratio of 0.063),and was higher in metastatic lymphatic tissue than that in adjacent non-neoplastic mucosa(with ratio of 35.482).The mRNAL was higher in carcinoma and lymphatic tissues in sinus ventriculi than those in corpus ventriculi with ratioes of 3.074 and 9.190 respectively.The mRNAL was higher in cancer and metastatic lymphatic tissues of metastasis group than those of non-metastatic group with ratioes of 9.912 and 59.912 respectively.The mRNAL was higher in cancer and metastatic lymphatic tissues of group T2 than those of group ≤T2 with ratioes of 1.540 and 13.833 respectively,and the differences were statistically significant(P0.01).Conclusions:Gastrin has important significance in the development of gastric cancer.Its expression is highly correlated with situs,metastases and clinical manifestation of gastric cancer.
【Fund】: 贵州省国际科技合作重点项目资助[黔科合外G字(2008)700119]
【CateGory Index】: R735.2
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