Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Guiyang Medical College》 2013-03
Add to Favorite Get Latest Update

Design and Synthesis of Nicotinic Acid Ester Derivatives of Scutellarein with Improved Anti-oxidative Activity

XU Qingyun,FU Xiaozhong,YANG Guo,DONG Yongxi,LIU Ying,ZHA Yufeng, LAN Yanyu,WANG Yonglin,ZHENG Lin(School of Pharmacology,Guiyang Medical College,Guiyang 550004,Guizhou,China)  
Objective: To design and synthetize 4′-nicotinic acid ester derivatives of scutellarein with improved free radical scavenging activity and better physiochemical property.Methods: Scutellarein coupled with dichlorodiphenylmethane were adopted to prepare 6,7-diphenylketal protecting scutellarein by using diethylene glycol dimethyl ether(DME) as solvent under heating condition.The obtained compounds and substituted nicotinic acid were condensed to prepare 6,7-diphenylketal protecting scutellarein 4′-nicotinic acid ester derivatives(5a~5e) in the presence of coupling agent DCC/DMAP,and the protecting group was removed by using acetyl chloride/methanol system to generate the target compounds.Results: Five unreported 4′-nicotinic acid ester derivatives of scutellarein(6a~6e) were synthetized.The chemical structure of synthetized compounds and key intermediates were confirmed to have the same structure with the target compound by using methods of 1HNMR,ESI-MS and ESI-HRMS respectively.Conclusions: This synthetic method has good practicality and can be used in synthetizing scutellarein 4′-nicotinic acid ester derivatives.
【Fund】: 国家自然科学基金(81260473 81060359);; 贵州省科技厅攻关计划(2008)3028;; 贵州省中药现代化科技产业研究开发专项(2012)3013
【CateGory Index】: R914
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 2 Hits
1 Yan Yun-zhen(Chongqing Xiushan Chineses Medical Hospital,Xiushan 409900);Effect of breviscapine on cerebral ischemia-reperfusion injury[J];Sichuan Journal of Physiological Sciences;2008-03
2 WANG Long-zi1, LIU Zhao-ping2, WANG Ju-ying1, LIU Ping1, ZHANG Xiu-mei1(1.Institute of Pharmacology,School of Medicine; 2. Centre for New Drugs Evaluation, Shandong University, Jinan 250012, Shandong, China);Protective effect and mechanisms of scutellarin on focal brain ischemia-reperfusion injury in rats[J];Journal of Shandong University(Health Sciences);2006-02
【Co-citations】
Chinese Journal Full-text Database 7 Hits
1 WU Heng1,CHEN Li-ming2,ZHANG Shan-tang2 (1.College of Pharmacy,Anhui Medical University;2.Anhui Provincial Hospital,Hefei 230001);Application of HPLC to research of traditional Chinese medicine[J];Anhui Medical and Pharmaceutical Journal;2009-08
2 ZHANG Jing,GUO Hong,LIU Yan(Tianjin University of TCM,Tianjin 300193,China);Advances in Brain Protection of Erigeron Breviscapus(Vant.)Hand.-Mazz[J];Journal of Changchun University of Traditional Chinese Medicine;2011-05
3 ;白藜芦醇对胃癌细胞Ras相关结构域家族1A基因甲基化及表达的影响[J];Contemporary Medicine;2011-18
4 ZHOU Rong-Guang YAN Ze-Yua ZHAO Jia-Qiang XU Yongb(Institute for Drug Research and Development of Kunming Pharmaceutical Corporation,Kunming 650100,P.R.China)a(The Chemical Research Institute of Yunnan Province,Kunming 650228,P.R.China)b(Department of Pharmacology of TCM,Yunnan University of TCM,Kunming 650500,P.R.China);Preparation,Purification and Structural Characterization of Scutellarein[J];Chinese Journal of Spectroscopy Laboratory;2011-05
5 YANG Xia YANG Bo LIAO Xia-Li ZHANG Miao LIU Zhen-Kun(Faculty of Life Science and Technology,Kunming University of Science and Technology,Kunming 650500,P.R.China);Solubilization of Scutellarein by Different Type of Cyclodextrin Derivatives[J];Chinese Journal of Spectroscopy Laboratory;2012-03
6 Cui Lin1, Yu Hai-bin1, Li Qiang1, Liu Wei-hong1, Ma Chun-fen2 The First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou,Henan,China 450000 The Second Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou,Henan,China 450002;The Study of the Protect Effect of Scutellarin on the Endothelial Cells Induced by Hydrogen Peroxide[J];China Journal of Chinese Medicine;2011-01
7 Yang Limei1,3,Gu Jun2,3,Lin Mingjian3,Ge Qiang3,Li Lingzhi2,3(1.Pharmacy college,Tianjin Medical University,Tianjin 300070;2.Tianjin Key Laboratory of Occupational and Environmental Hazards Biomarkers,Tianjin 300193;3.Department of Pharmaceutical Chemistry,Medical Collage of Chinese People's Armed Police Forces,Tianjin 300162);Advances in research on breviscapine[J];Tianjin Pharmacy;2010-01
China Proceedings of conference Full-text Database 1 Hits
1 SONG Yan,ZHANG Hong-mei,MA Jian-jian,CHE Qing-ming,LI Chang-ling (School of Pharmaceutical Sciences,Peking University Health Science Center,Beijing100191,China);Protection of Scutellarein on cerebral ischemia in rats[A];[C];2010
【Secondary Citations】
Chinese Journal Full-text Database 5 Hits
1 ZHANG Xiao bing, PENG Dai yin, ZHU Man fang,ZHOU Ya Qiu, LIU Qing yun (Department of Pharmacy, Anhui College of Traditional Chinese Medicine,Anhui Hefei 230038,China);Protective Effect of Breviscapine Dropping Pill Against Focal Cerebral Ischemia Reperfusion Injury in Rats[J];Journal of Anhui Traditional Chinese Medical College;2003-01
2 FU Zhao Di, CAO Yu, WANG Kai Feng, XU Shao Feng, HAN Rui Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P.R.China;Chemopreventive Effect of Resveratrol to Cancer[J];Chinese Journal of Cancer;2004-08
3 ZHOU Le-quan,KANG Ya-li,YAN Fu-man,Ding Sheng-yuan,Li Xiao-ying(Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,China);Effects of breviscapine on the intracellular calcium concentration of the hippocampal neurons in rats with pantobrain ischemia-reperfusion[J];Journal of Guangdong Medical College;2007-01
4 Peng Haidong 1,Tu Jinwen 2,Tian Jun 3 1. Department of TCM,Changzheng Hospital,Second Military Medical University,Shanghai 200003 2. Department of Physician,The Subsidiary Hospital of Hubei College of TCM,Wuhan 430061 3. Department of Physician,Th;Effects of Breviscapine on Contents of Water and Calcium of Brain after Cerebral Ischemia-reperfusion in Rats[J];Jounal of Hubei College of Trditional Chinese Medicine;2002-03
5 Chu Zhaohu,Wu Jiami,Liu Fudong,et al.Department of Neurology,Yi Jishan Hospital.Wannan Medical College, Wuhu 241001;Neuronal apoptosis during cerebral ischemic reperfusive injury and the expression of its regulating gene in rats[J];JOURNAL OF CLINICAL NEUROLOGY;2000-03
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved