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《Journal of Guiyang Medical College》 2015-11
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Expression Analysis of Gastrin and Its Receptor in Gastric Cancer and Precancerous Lesions

XIE Yuan;ZHAO Yan;LIU Zhengmei;GUAN Zhizhong;ZHOU Jianjiang;Key Laboratory of Molecular Biology,Guihzou Medical University;  
Objective: To observe gastrin and CCK-BR expression in gastric cancer and precancerous lesions and to explore the relationship between gastrin and CCK-BR and the development of gastric cancer. Methods: The gastric tissues of patients undergoing gastroscopy in the digestive endoscopy center were collected. According to the histopathological diagnosis,patients were divided into 4 groups and total RNA was extracted and purified from gastric tissues,then,gastrin and CCK-BR mRNA levels were determined with Taqman real-time quantitative PCR. Results: Gastrin and its receptor CCK-BR expressed in gastric carcinoma and precancerous lesions. The expression of gastrin in gastritis,intestinal metaplasia,atypical hyperplasia group was higher than that in gastric cancer group,with ratio of2. 37,1. 67,1. 9 times of gastric cancer group,the difference was statistically significant( P 0. 05).The expression of CCK-BR in gastritis,intestinal metaplasia,atypical hyperplasia group was also higher than that in gastric cancer group,with ratio of 1. 62、3. 66、1. 33 times of gastric cancer group,the difference was statistically significant( P 0. 05). Conclusions: Gastrin and its receptor CCK-BR expression in gastric cancer tissues is lower than those in the precancerous lesions.
【Fund】: 国家自然科学基金资助项目(81260303);; 贵州省2011协同创新中心支助项目[黔教合协同创新(2014)06]
【CateGory Index】: R735.2
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