Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Guiyang Medical College》 2015-11
Add to Favorite Get Latest Update

Expression Analysis of Gastrin and Its Receptor in Gastric Cancer and Precancerous Lesions

XIE Yuan;ZHAO Yan;LIU Zhengmei;GUAN Zhizhong;ZHOU Jianjiang;Key Laboratory of Molecular Biology,Guihzou Medical University;  
Objective: To observe gastrin and CCK-BR expression in gastric cancer and precancerous lesions and to explore the relationship between gastrin and CCK-BR and the development of gastric cancer. Methods: The gastric tissues of patients undergoing gastroscopy in the digestive endoscopy center were collected. According to the histopathological diagnosis,patients were divided into 4 groups and total RNA was extracted and purified from gastric tissues,then,gastrin and CCK-BR mRNA levels were determined with Taqman real-time quantitative PCR. Results: Gastrin and its receptor CCK-BR expressed in gastric carcinoma and precancerous lesions. The expression of gastrin in gastritis,intestinal metaplasia,atypical hyperplasia group was higher than that in gastric cancer group,with ratio of2. 37,1. 67,1. 9 times of gastric cancer group,the difference was statistically significant( P 0. 05).The expression of CCK-BR in gastritis,intestinal metaplasia,atypical hyperplasia group was also higher than that in gastric cancer group,with ratio of 1. 62、3. 66、1. 33 times of gastric cancer group,the difference was statistically significant( P 0. 05). Conclusions: Gastrin and its receptor CCK-BR expression in gastric cancer tissues is lower than those in the precancerous lesions.
【Fund】: 国家自然科学基金资助项目(81260303);; 贵州省2011协同创新中心支助项目[黔教合协同创新(2014)06]
【CateGory Index】: R735.2
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 2 Hits
1 ZENG Yi;ZHOU Jian-Jiang;XIE Yuan;ZHAO Yan;Key Laboratory of Molecular Biology of Guiyang Medical College;Department of Laboratory,Affiliated Hospital of Guiyang Medical College;;Gastrin Silencing Inhibits Cell Proliferation,Migration and Invasion in Cultures[J];Chinese Journal of Biochemistry and Molecular Biology;2014-09
2 ;The relationship between peptic ulcer, gastric carcinoma and G cells in gastric antrum[J];Chinese Journal of Gastroenterology and Hepatology;2003-04
【Co-citations】
Chinese Journal Full-text Database 5 Hits
1 ZHAO Yan1,XIE Yuan1,WANG Wenling2,WANG Su1,CHEN Xian1,ZHOU Jianjiang1,2 (1.The Key Laboratory of Molecular Biology,Guiyang Medical College,Guiyang 550004,Guizhou,China;2.Department of Internal Medicine,Cancer Hospital of Guizhou Province,Guiyang 550004,Guizhou,China);Expression of Gastrin Gene in Human Gastric Cancer Tissues and Metastatic Lymphatic Tissues[J];Journal of Guiyang Medical College;2011-03
2 ZHENG Li-Hong;ZHANG Ying-Bo;WANG Xiao-Li;LU Chang-Fang;FAN Li;CONG Huan;YUE Li-Ling;Department of Biology Genetics,Qiqihar Medical University;Research Institute of Medical Science and pharmacy,Qiqihar Medical University;Department of Pharmacology,Qiqihar Medical University;;Exogenetic Overexpression of FUT8 Increases the Ability of Migration and Invasion in Breast Cancer Cells[J];Chinese Journal of Biochemistry and Molecular Biology;2015-07
3 GUO Shui-long;ZHU Sheng-tao;LI Peng;WANG Yong-jun;WANG Min;XING Jie;GUO Qing-dong;SUN Xiu-mei;ZHANG Shu-tian;Beijing Friendship Hospital,Capital Medical University;Beijing Key Laboratory for Precancerous Lesion of Digestive Disease;Beijing Digestive Disease Center;;Gastric cancer related miR-148a targets gastrin receptor CCKBR[J];Chinese Journal of Comparative Medicine;2014-09
4 RU Tong;LIU Tie-fu;Department of Gastroenterology,the Fourth Affiliated Hospital of Harbin Medical University;;Progress in Diagnosis of Gastric Cancer[J];Medical Recapitulate;2014-24
5 CHEN Moye;XU Qian;SUN Liping;SUN Mingjun;Department of Gastroenterology,the First Affiliated Hospital of China Medical University;Tumor Etiology and Screening Department of Cancer Institute and General Surgery,the First Affiliated Hospital of China Medical University,and Key laboratory of Cancer Etiology and Prevention ( China Medical University) ,Liaoning Provincial Eudcation Department;;The association between serum G17 and precancerous disease and gastric cancer[J];Chinese Journal of Gastroenterology and Hepatology;2015-02
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 JIANG Meng-jun, XIAO Zhi-jian, ZHANG Rong-jun, et al. (State Key Laboratory of Nuclear Medicine, Institute of Nuclear Medicine, Wuxi 214063, China);Clinical Significance of Combined Determination of PGⅠ, PGⅡ and GAS for Diagnosis in Gastric Cancer[J];Labeled Immunoassays and Clinical Medicine;2004-03
2 Liu Yan1,Geng Paili1,Lü Youyong2(1.Qinghai University Medical College;2.Peking University School of Oncology,Laboratory of Molecular Biology);SHRNA-MEDIATED SILENCING OF THE GASTRIN GENE INHIBITS THE PROLIFERATION AND MIGRATION OF HUMAN GASTRIC CANCER CELL BGC823[J];Journal of Qinghai Medical College;2010-01
3 ZHANG Shu-Hua 1) , GE Yin-Lin 1)* , LUO Da-Ya 2) , TIAN Run-Hua 1) ( 1) Department of Biochemistry and Molecular Biology, Medical College, Qingdao University, Qingdao 266021, Shandong, China; 2) Department of Biochemistry and Molecular Biology,Basic Medical College,Nanchang University,Nanchang 330006,China);Small Interfering RNAs Directed Against VEGF Gene Inhibit Proliferation of Breast Cancer Cells in Vitro and in Vivo[J];Chinese Journal of Biochemistry and Molecular Biology;2007-01
4 LIU Jun1),ZHOU Jian-Jiang1),2) ,XIE Yuan1),ZHAO Yan1),ZENG Yi1)(1) Key Laboratory of Molecular Biology of Guiyang Medical College,Guiyang 550004,China; 2) Affiliated Hospital of Guiyang Medical College,Guiyang 550004,China);Overexpression of Gastrin Promotes the Proliferation,Migration and Invasion of Gastric Cancer Cells[J];Chinese Journal of Biochemistry and Molecular Biology;2013-04
5 CAO Qin,RAN Zhihua,XIAO Shudong Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200001, China;Usefulness of gastric cancer screening using the serum pepsinogen and gastrin-17[J];Chinese Journal of Gastroenterology and Hepatology;2007-04
6 REN Wei,YU Li-xia, QIAN Xiao-ping, et al. (The Affiliated Drum Tower Hospital of Medical School of Nanjing University, Nanjing 210008, China);Expression of Serum VEGF and MMP-2 in Gastric Carcinoma and its Relationship with Invasion and Metastasis[J];Journal of Oncology;2008-10
7 LIU Cuixia,SHAO Yun,LI Jianpin,et al.Department of Geriatric Gastroenterology,First Affiliated Hospital,Nanjing Medical University,Nanjing 210029,CHINA;Effects of gastrin on the proliferation and cyclooxygenase-2 expression in gastric cancer cells[J];Jiangsu Medical Journal;2010-04
8 SUN Peng1,LI Hongyan2,HU Peng2,XU Ruihuan1 (1.The Sixth People's Hospital of Shenzhen City,Shenzhen 518052,China; 2.Fapon Biotech Inc.,Shenzhen 518054,China);Research of the relationship of gastrin and gastrin receptor antagonist proglumide and the expression of protein P16 as well as P21 in BGC-823 gastric cancer cell line[J];China Medical Herald;2009-32
9 LIAO Tianhu Department of Surgery,the No.2 People′s Hospital of Ba′nan District in Chongqing City,Chongqing 401321,China;Clinical analysis on determination of serum gastrin and IGF-Ⅰ levels in patients with gastric cancer before and after operation[J];China Medical Herald;2011-24
10 XU Xiu-ying1,WANG Ying1,JIANG Ruo-lan1,LU Xiang-lan2,ZONG Zhi-hong3(1.Department of Gastroenterology,The First Affiliated Hospital,China Medical University,Shenyang 110001,China;2.Department of Hematology,The First Affiliated Hospital;3.Department of Biochemistry and Molecular Biology,College of Basic Medical Sciences);Effect of gastrin on growth of human gastric cancer cell line BGC-823 and post-receptor signal transduction mediated by gastrin[J];Journal of China Medical University;2006-06
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved