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《Guangxi Medical Journal》 2002-04
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Study on orthogonal table design for the reasonal scheme of administrating antibiotics in cesarean section

Cheng Shaowai,Teng Fenglan,Ma Haoling,et al Liuzhou Central Railway Hospital(Liuzhou 545007)  
Objective:A prospective study on administrating antibiotics for preventing postoperative infections of cesarean section was carried out in order to provide a basis for selection of administration scheme Methods:By using L 8(4×2 4) orthoganal table design,8 schemes with different administration factors and levels were designed 293 cases cesarean section were randomly divided into groups and each group received on scheme with thirty five repetitions Clinical indices for infection were odserved Results:(1)No postoperative infectious complications occurred in all groups All wounds healed in grade A (2) There were significant differences between some factors or levels in patients temperature and hemogram Conclusion:(1)For preventing infection,a scheme of single drug and short course may be adopted As a routime,cefezolin is the drug of choice and in case of neutrocytosis,rocephin may be given,in case of leucocytosis,cefezolin and metronidazole may be given together,preventing infections (2)Orthogonal table design is a good method for optimizing drug administration scheme on drug utilization and phamacoeconomics study
【CateGory Index】: R719.8
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