Experimental study on the in vivo antitumor effect of the total flavonoids from radix glycyrrhizae

ZHAO Shi-yuan,NONG Zhi-xin,ZHONG Zhen-guo. The Center of Experiment,The Hospital of Nationality of Guangxi(nanning 530001),china  

Objective To explore in vivo anti-tumor effects of the total flavonoids from radix glycyrrhizae;and to provide the scientific evidence for developing and manufacturing new antitumor drugs.Methods The graft mouse tumor model S_ 180 was used to investigate the active effects of the total flavonoidls from radix glycyrrhizae on tumor growth and the weights of immune organs.The graft tumor model H_ 22 was used to investigate the total flavonoids from radix glycyrrhizae effect on tumor growth and the lifetime of tumor mice.Results The total flavonoids from radix glycyrrhizae had obvious effects of tumor inhibition.It was noted that tumor formation postponed in mice treated with the total flavonoids from radix glycyrrhizae compared with the control panel and tumor growth became slower;The total flavonoids from radix glycyrrhizae could also increase index of thymus in mice with graft tumor,and it decreased index of spleen.Conclusion The results suggest that the total flavonoids from radix glycyrrhizae can inhibit tumor growth and prolong the lifetime of the tumor-bearing mice in a dose-dependent pattern.The mechanism may be improving the function of immune system,inhibiting the growth of tumor cells and accelerate tumor cell necrosis.

【Key Words】： Total flavonoids Radix glycyrrhizae Tumor inhibition In vivo Index of thymus Index of spleen
【Fund】： 广西医疗卫生科研课题(Z2005009)
【CateGory Index】： R285

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