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Studies on invigorating energy,activating blood flow,resolving blood stasis and anti-aging actions of alcohol extracts of Codonopsis Lanccolata

XU Qin,CHEN Xiao-jun,LIU Bu-ming,YANG Ping,Bai Xian-qun,Deng Li-dong,CHEN Xue-fen(1 Department of Pharmaceutical Analysis,Guilin Medical College,Guilin 541004,China;2 Department of basic medical science,Guilin Medical College,Guilin 541004,China;3 Guangxi Institute of Traditional Medical and Pharmaceutical Sciences,Nanning 530022,China;4 Department of Pharmacy,Guilin Medical College Affiliated Hospital,Guilin 541001,China)  
Objective To study the effects of invigorating energy,activating blood flow,resolving blood stasis and anti-aging of alcohol extract of Codonopsis lanccolata in rats and mice.Methods Each item of hemorheology of alcohol extract of Codonopsis lanccolata on animal model of Qi-deficiency and blood stasis syndrome in rats was observed.The time of pole-climbing,the time of antianoxia,weights of immune organs(thymus and spleen) on the 7th day and 14th day after gavaged with the extract for 14 days were measured.Results The effects of alcohol extract on rats with Qi-deficiency and blood stasis syndrome showd whole blood viscosity(high-sheer,middle-sheer,low-sheer),plasma viscosity,aggregation indexes of red blood cells,packed red blood cell were decreased significantly and red blood cell electrodeposition time was speed up significantly.The group of high dose of alcohol extract of Codonopsis lanccolata extended the time of antianoxia significantly on the 7th day and 14th day,the group of low dose of alcohol extract of Codonopsis lanccolata extended the time of antianoxia significantly on the 14th day.Both of the group of high dose and low dose of alcohol extract increased thymus weights of mice's significantly on the 7th day and 14th day and pleen weights of mice'ss on the 14th day.Conclusion It was initially judged that alcohol extract of Codonopsis lanceolata had the effects of invigorating energy,activating blood flow and resolving blood stasis on rats and anti-aging on mice.
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