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《Guangxi Medical Journal》 2009-06
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Methylprednisolone of Intratympanic Injection for Refractory Sudden Sensorineural Hearing Loss

Shao Jun,Guo Guang-wei,Su Ji-ping(Department of Otolaryngology and Head and Neck Surgery,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China)  
Objective To observe the clinical efficacy of intratympanic Methylprednisolone injection(IMI) for patients with sudden sensorineural hearing loss(SSHL)and we will investigate the effective treatment for SSHL patients who failed to respond to systemic corticosteroid treatment.Methods 47 SSHL cases(47 ears) which failed to respond to regular treatments were injected methylprednisolone 0.5 ml(20 mg) to the tympanic cavity every three days,4 times in all,make sure the round window niches were involved.Pure-tone average(PTA) was tested before and 3 days after the IMI and it was considered to be effective when the improvement of PTA was more than 15 dB HL.Results PTA of post-injection(67.59±16.57) dB HL was lower than the pre-injection(53.65±18.75) dB HL(P=0.000).All of 47 patients,14 patients showed improvement,and 33 patients failed,the effective rate was 29.8%.Promising results of IMI were found in cases with shorter duration or/and without vertigo.Tinnitus and diabetes have no impaction on the treatment.Conclusion IMI can be applied to SSHL patients who failed to respond to systemic corticosteroid treatment and it can avoid the side-effects brought on by high dose systemic corticosteroid treatment.
【Fund】: 广西教育厅科研项目基金(桂教科研[2003]22号)
【CateGory Index】: R764.437
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 SU Jiping 1 Bachmann G 2 TANG Anzhou 1 Zumegen C 2 Michel O 2 Wittekindt C 2 ( 1Department of Otolaryngology, First Affiliated Hospital, Guangxi Medical University, Nanning 530021; 2Klinik und Poliklinik für Hals , Nasen , Ohrenheilkunde, der Universitt zu Kln);The different levels of prednisolone in perilymph after local and systemic treatment[J];Journal of Clinical Otorhinolaryngology;2003-10
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【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 JIANG Xuefan1),SU Lizhong1),WANG Junbo2).1)Department of Otolaryngology,Zhejiang Provincial People's Hospital,Hangzhou 310014,Zhejiang;2)Department of Clinical Medicine,School of Medical & Life Sciences,Zhejiang University City College;The curative effect observation of dexamethasone on sudden deafness[J];Clinical Medicine;2008-02
2 JIANG Xuefan1),WANG Junbo2),SU Lizhong1).1)Department of Otolaryngology,Zhejiang Provincial People's Hospital,Hangzhou 310014,Zhejiang;2)Department of Clinical Medicine,School of Medical & Life Sciences,Zhejiang University City College;The curative effect observation of hyperbaric oxygen on sudden deafness[J];Clinical Medicine;2008-03
3 FENG Wenjing1,LIU Bo2,PENG Xiaoxia3, LIAN Nengjing2, NIU Leifang2(1 2005 post-graduate student, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China; 2 Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education, Beijing Institute of Otolaryngology, Beijing, 100005, China; 3 Department of Epidemiology and Health Statistics, School of Public Health and FamilyMedicine, Capital Medical University, Beijing, 100069, China);The study of risk factors of sudden hearing loss[J];Chinese Archives of Otolaryngology-Head and Neck Surgery;2008-06
4 JI Qing~1 LIU Ying~1 WANG Yuan~2 WANG Qi~3 1 Department of Otolaryngology,th e Hospital of Tsinghua University,Beijing,100084,China; 2 Department of Otolaryngology,the General Hospital of China Aerospace Science and Technology Corporation,Beijing,100076,China; 3 Department of Otolaryngology Head and Neck Surgery,Beijing Tongren Hospital,Capital Medical University,Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University),Ministry of Education,Beijing,100730,China;Clinical analysis of idiopathic sudden sensorineural hearing loss[J];Chinese Archives of Otolaryngology-Head and Neck Surgery;2008-07
5 CHEN Gang, HOU Shi-xiang~△, LIU Jun, LUAN Jian-gang, ZHANG Yu. Department of Pharmaceutical Sciences, West China School of Pharmacy,Sichuan University, Chengdu 610041, China;In vivo Distribution and Pharmacokinetics of Dexamethasone Sodium Phosphate Thermosensitive in situ Gel Following Intratympanic Injection[J];Journal of Sichuan University(Medical Science Edition);2006-03
6 Yan Xukun,Dai Pu,Xue Xijun,et al.Department of Otolaryngology,Kunming General Hospital of Chengdu Command,Kunming 650032,China;Analysis of mitochondrial DNA gene mutations in hearing loss induced by military noise[J];Medical Journal of Chinese People's Liberation Army;2008-03
7 LI Sui 1 GONG Shusheng 1 CHEN Jianguo 2 LU Haitao 1 WANG Jibao 1 ( 1Department of Otolaryngology,Union Hospital, Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430022,China; 2Department of Pharmacology,Tongji Medical College,Huazhong University of Science and Technology);Pharmacokinetics of the methylprednisolone,dexamethasone and hydrocortisone in the inner ear after administered via round window[J];Journal of Clinical Otorhinolaryngology;2005-01
8 HOU Dongming 1 WU Hao 1 YANG Jun 1 ZHANG Ping 1 ZHANG Shunguo 2 CHEN Jie 1 ( 1Department of Otorhinolaryngology-Head and Neck Surgery,Xinhua Hospital,Shanghai Second Medical University,Shanghai,200092,China; 2Department of Clinical Pharmacology, Xinhua Hospital, Shanghai Second Medical University);Dexamethasone pharmacokinetics in perilymph of guinea pig after different topical administrations[J];Journal of Clinical Otorhinolaryngology;2005-07
9 ZHANG Ping~1 WU Hao~1 YANG Jun~1 HOU Dongming~1 ZHANG Shunguo~2 CHEN Jie~1(~1Department of Otorhinolaryngology and Head-neck Surgery,Xinhua Hospital,Shanghai Second Medical University,Shanghai,200092,China;~2Department of Clinical Pharmacology,Xinhua Hospital affiliated Shanghai Second Medical University);Methylprednisolone pharmacokinetics in perilymph and plasma of guinea pig after topical administration and intracardial injection[J];Journal of Clinical Otorhinolaryngology;2005-22
10 REN Jihao LU Yongde YIN Tuanfang LIU Bin GE Yilin (Department of Otolaryngology, the Second Hospital of Xiangya Medical College, Central South University, Changsha, 410011, China);Intratympanic dexamethasone injections for intractable sudden sensorineural hearing loss[J];Journal of Clinical Otorhinolaryngology;2006-05
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