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《Guangxi Medical Journal》 2009-07
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A Study of Chronic Liver Injury Model Induced by 40% Carbon Tetrachloride

LIN Lin,LIU Han-feng(Department of Oncology,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China)  
Objective To explore the pathological changes of chronic liver injury induced by carbon tetrachloride in rat.Methods Sixty female Wistar rats were divided into control group(n=30) and experimental group(n=30) by mean of random number table.Rats in control group were intraperitoneal injected with corn oil,0.1 ml/100 g,twice per week;rats in experimental group were intraperitoneal injected with 40% carbon tetrachloride 0.1 ml/100 g,twice a week.They were sacrificed at 48 hours after poisoning in the 2nd,4th and 6th week respectively,then the liver were taken out and sections stained by hematoxylin-eosin,the sections were examined under light microscope.Results Of the liver tissue sections in experimental groups,fatty degeneration and breakage as well as little fibroustissue hyperplasia of liver lobule were observed after poisoning in the 1st week.By the 4th week,cirrhosis of liver was observed.The appearance of serious liver cirrhosis and formation of pseudolobule were observed at the 6th week.Conclusion After poisoning with 40% carbon tetrachloride,the liver injuries get severer and liver cirrhosis are observed in 6th week.
【Fund】: 广西科学基金(桂科自0832136)
【CateGory Index】: R575
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