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《Chinese Journal of Bone Tumor and Bone Disease》 2005-05
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The clinical observation of hereditary multiple exostoses of one pedigree of Tujiazu nation

TANG Changyou,PENG Wuzhi, XIANG Qingguo, et al. Department of Orthopaedics, XIANG-Xi Prefecture Hospital of TCM, Jishou,416000 China  
Objective To study the distribution and regularity of Tujiazu nation hereditary multiple exostoses (HME) by analysing t of one pedigree in Xiangxi minority nation region in Hunan. Methods One HME pedigree which had been clinically and pathologically confirmed were studied. Results 34 patients diagnosed as HME and 67.65% were male and 32.35% were female. Patients who located in the pedigrees of 4th,5th generation had the severest symptomatic lesions. The most common location of exostosis was juxta-epiphyseal regions of the long bones. However, no exostoses was found in skull, mandible and clavicle. Conclusions These is no incidence difference between Hangzu and Tujiazu and there is gender difference in the incidence of HME (malefemale). The clinical phenotypes of HME are passed down more severely from generation to generation with the selective feature in the location of exostosis. This study may devote to the elucidation of the mechanism and the relationship between phenotypes and genotypes of HME and there may be some similarities and differences in the HME of TU Jiazu nation.
【CateGory Index】: R738;
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