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《Chinese Journal of Bone Tumor and Bone Disease》 2005-06
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Clinicopathology analasis of 15 cases of primary mesenchymal chondrosarcoma in bone and soft tissue

Cai Lei Gao Zifen Huang Xiaoyuan Department of Pathology,Beijing Jishuitan Hospital Beijing 100035,China  
Objective To investigate the clinical and pathologic characteristics,diagnosis and differen- tial diagnosis of primary bone and soft tissue mesenchymal chondrosarcoma.Methods Clinical data and pathologic slides(HE and immunohistochemical stains)of 15 cases of primary bone and soft tissue mes- enchymal chondrosarcoma was reviewed.Results These 15 cases of mesenchymal chondrosarcoma rep- resent 9.4% of all chondrosarcomas patients admitted in authors hospital between 1995 and 2005.The ages of the patients ranged from 14 to 70 years and approximately 80% of them were in the second to forth decades of life.Tow cases arose in soft tissue and five cases involved multiple skeletal sites.Pain and swelling are the main complains.The bone lesions resembled classic chondrosarcomas in image. Histologically,atypical undifferentiated small cells and islands of matured chondroid matrix typically pre- sented a bimorphic appearances and there is a distinct border between these two materials.Prognosis for patients with mesenchymal chondrosarcoma is usually poor and especially in the older patients.Con- clusions Mesenchymal chondrosarcoma is a rare disease with poor prognosis.It is nessesary to distin- guish it from Ewings sarcoma and small cell osteosarcoma,and other small cell malignant tumors.His- tological characteristics and immunohistochemical results are helpful for diagnosis and differentiated diag- nosis.
【CateGory Index】: R738
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