Full-Text Search：
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Modern Food Science and Technology》 2007-11
Add to Favorite Get Latest Update

Effects and Mechanism of the Inhibition of H22 Hepatocarcinoma Cell Growth by Cartilage Polysaccharide

LIU An-jun, CHEN Yan-yan, ZHANG Guo-rong, CHE Wei, MENG Yan-li (College of Food Engineering & Biotechnology, Tianjin University of Science & Technology, Tianjin 300457, China)  
The effect and mechanism of inhibition of H22 Hepatocarcinoma cell growth by cartilage polysaccharides (CA) were studied. Transplanted H22 hepatocarcinoma was used as the model and the mice were randomly divided into 2 group, the control group and CA group. The growth and apoptosis of the tumor cell were investigated by HE Staining, terminal-deoxynucleotidyl transferase mediated nick end labeling (TUNEL), flow cytometry (FCM) and immunofluorescent staining. Results showed that CA could induce the apoptosis of the H22 cell, inhibit the growth of tumor and prolong the life span time of the examined mice. Besides, increasing the time after taking medicine could enhance the expression of P21 protein in the CA group and inhibit the expression of Cyclin D1. As a new anti-cancer agent, CA had wide application prospects.
【Key Words】： cartilage polysaccharide H22 hepatocarcinoma cell apoptosis
【Fund】： 国家自然科学基金项目(NO.20776113)
【CateGory Index】： R735.7
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 4 Hits
1 LIUAn-jun,ZHAO Xi-hua,ZHANG Guo-rong,Han xue,LIANG Ling-ling,ZHANG Cheng(College of Food Engineering and Biotechnology,Tianjin University of Science andTechnology,Tianjin 300457,China);Immunoprotection Effects of Cartilage Polysaccharide and Inactivated S180 on Tumor-bearing Mice[J];Modern Food Science and Technology;2008-11
2 ZHANG Guo-rong,LANG Jing,LIU Yan-ling,LIU An-jun(College of Food Engineering and Biotechnology,Tianjin University of Science & Technology,Tianjin 300457,China);Preliminary Study of the Inhibitory Effect of Selenic Acid Cartilage Polysaccharide on Hca-F Hepatocarcinoma Tumor-bearing Mice[J];Modern Food Science and Technology;2008-12
3 HAN Xue1, LIU An-jun1, ZHAO Xi-hua1, LI Yan-dong2 (1.College of Food Engineering and Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China)(2.Key Laboratory of Zoonosis research, Ministry of Education, Jilin University, Changchun 130062, China);Cell-mediated Antitumor Immunity Response to Hepatocarcinoma Vaccine with Cartilage Polysaccharide as Immunoadjuvant[J];Modern Food Science and Technology;2009-07
4 ZHANG Guo-rong, ZHANG Hong, LIU An-jun, CHEN Hong-shuo (College of Food Engineering and Biotechnology, Tianjin University of Science and Technology, Tianjin30045, China);Extraction, Separation and Characterization of Three Kinds of Cartilage Polysaccharides[J];Modern Food Science and Technology;2009-08
【Citations】
Chinese Journal Full-text Database 1 Hits
1 SUN Yu-shu, BI Li-fu, SU Xiu-lan(Research Center of Molecular Biology,Inner Mongolia Medical College,Hohhot 010059 China);GENERAL RESEARCH SITUATION OF POLYSACCHARIDES AND POLYSACCHARIDES MEDICINE[J];Acta Academiae Medicinae Neimongol;2006-01
【Co-citations】
Chinese Journal Full-text Database 2 Hits
1 JI Chen-feng, ZOU Xiang ,GAO Shi-yong ,JI Yu-bin (Postdoctoral Research of Institute of Materia Medica,Harbin University of Commerce, Harbin 150076, China);Study on anti-tumor effect of three kinds of cactus polysaccharide[J];Journal of Harbin University of Commerce(Sciences Edition);2004-02
2 ZHANG Xiao-di1,2,LI Yong-jian2(1.Shanghai Traditional Chinese Medical University,Shanghai 200032,China;2.Suzhou Traditional Chinese Medical Hospital,Suzhou 215003,Jiangsu,China);A Review on Treating Caner by Wen Yang Method[J];Journal of Liaoning University of Traditional Chinese Medicine;2009-06
【Co-references】
Chinese Journal Full-text Database 8 Hits
1 LIU Cong, ZHOU Sheng, KE Chang-Shu, LI Na-Ping, WU Ren-Liang Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, P. R. China;Activation and Prognostic Significance of AKT, NF-кB and STAT3 in Breast Cancer with Lymph Node Metastasis and Estrogen Receptor Expression[J];Chinese Journal of Cancer;2007-09
2 LIU An-jun, CHEN Ying, ZHANG Guo-rong (College of Food Engineering & Biotechnology, Tianjin University of Science & Technology, Tianjin 300457,China);Protective Effect of Collagen Polypeptide-chromium Chelate in Alloxan-treated HL 7702 Hepatocytes[J];Modern Food Science and Technology;2008-02
3 LIUAn-jun,ZHAO Xi-hua,ZHANG Guo-rong,Han xue,LIANG Ling-ling,ZHANG Cheng(College of Food Engineering and Biotechnology,Tianjin University of Science andTechnology,Tianjin 300457,China);Immunoprotection Effects of Cartilage Polysaccharide and Inactivated S180 on Tumor-bearing Mice[J];Modern Food Science and Technology;2008-11
4 MIAO Ben-chun, GENG Mei-yu, LIjing, et al.(Institute of Marine Drug and Food, Ocean University of Qingdao, Qingdao 266003, China);A Study on Immunopotentiating Activity of Marine Sulfated Polysaccharide 911[J];Chinese Journal of Marine Drugs;2002-05
5 MIAO Ben-chun,LI Jing,GENG Mei-yu,et al. (Institute of Marine Drug and Food ,Ocean University of China ,Qingdao 266003 ,China);A study on antitumor mechanisms of marine sulfated polysac- charide poly-guluronic acid (912)[J];Chinese Journal of Marine Drugs;2003-03
6 WANG Chun-ling~(1),ZHANG Quan-bin~(2)(1.The Medical School Hospital of Qingdao University,Qingdao 266003,China;2.Institute of Oceanology,Chinese Academy of Sciences,Qingdao 266071,China);Studies on anticoagulant activity of fucoidan[J];Chinese Journal of Marine Drugs;2005-05
7 CONG Jian Bo ①,WANG Chang Zhen,LI Yan ②,WU Ke ( ①Institute of Radiation and Medicine,Academy of Military Medical Sciences,Beijing 100850 China) ( ②Institute for Drug Instrument Control of Beijing Command,Beijing 100071 China);Investigation of Barium Sulfate Turbidimetry on Determination the Sulfated Group of Sulfated Polysaccharides[J];Pharmaceutical Journal of Chinese People's Liberation Army;2003-03
8 MENG Xing-kai, WANG Wan-xiang, Bao Li-dao,et al.(Department of Surgery,Affiliated Hospital,Inner Mongolia Medical College,Hohhot,010050 China);A COMPARATIVE STUDY OF VARIOUS SURGICAL PROCEDURES ON HEPATIC HYDATID CYSTS[J];Acta Academiae Medicinae Neimongol;2005-03
【Secondary References】
Chinese Journal Full-text Database 2 Hits
1 HAN Xue1, LIU An-jun1, ZHAO Xi-hua1, LI Yan-dong2 (1.College of Food Engineering and Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China)(2.Key Laboratory of Zoonosis research, Ministry of Education, Jilin University, Changchun 130062, China);Cell-mediated Antitumor Immunity Response to Hepatocarcinoma Vaccine with Cartilage Polysaccharide as Immunoadjuvant[J];Modern Food Science and Technology;2009-07
2 ZHANG Guo-rong, ZHANG Hong, LIU An-jun, LIU Ying-fen (College of Food Engineering and Biotechnology, Tianjin University of Science and Technology, Tianjin30045,China);Preventive Effect of Cartilage Polysaccharide on Rheumatoid Arthritis in Mice[J];Modern Food Science and Technology;2009-09
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Li jing; Zhuo xongjun(Guangzhou Institude of Chemistry , The Chinese Academy of, Guangzhou 510650 China);Determination of molecular weight and relative content of the Component of polysaccharide krestin with aqueous gel permeation chromatography[J];GUANGZHOU CHEMISTRY;1998-04
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved