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The Effects of Sinomenine on Rat Behavior and the Range of Cerebral Infarction after Focal Brain Ischemia-Reperfusion

Liang Jian; Zheng Pingxiang; Liang Jingsheng (Department of Pharmacology, Guangzhou Medical College, Guangzhou 510182)  
The article studied the protective effects of sinomenine (Sin) on nerve dysfunction, cerebral edema and the range of cerebral infarction after focal brain ischemia-reperfusion injury in rats, by using experimental model of reversible middle cerebral artery occlusion without craniectomy. The results showed that in the condition of 2h brain ischemia + 4h reperfusion the range of cerebral infarction was 29. 6 5. 3%, the water content of the brain tissue was 83. 05 0. 54 %, and obvious nerve dysfunction occurred. On condition that sinomenine was injected peritoneally 10 min before the occlusion of coddle cerebral artery at the doses of 30 and 60mg/kg, the extent of behavior disorder, cerebral edema and the range of cerebral infarction were obviously reduced. The present study indicates that sinomenine possesses a protective action on focal brain ischemia-reperfusion injury in rats.
【CateGory Index】: R965
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