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《Academic Journal of Guangzhou Medical College》 2006-02
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The Effects of Platelet-Derived Growth Factor-BB on the Attachment and Proliferation of Periodontal Ligament Cells on Root Surface

ZHOU Quan~1,JI Jian-xin~1,LIAO Wei-jiao~2,QIU Zhi-hui~3,PAN Guang-ci~1,LIU Xi-hong~4,ZHANG Ting~2(~1Dept.of Stomatology,First Affiliated Hospital,Guangzhou Medical College,Guangzhou,Guangdong 510120;~2Dept.of Laboratory Investigation,First Affiliated Hospital,Guangzhou Medical College,Guangzhou,Guangdong 510120;~3Guangzhou Institute of Respiratory Diseases,Guangzhou Medical College Guangzhou,Guangdong 510120;~4Central Laboratory,Guangzhou Medical College Guangzhou,Guangdong 510182,China)  
Objective:To evaluate the effects of platelet-derived growth factor-BB(PDGF-BB) on the attachment and proliferation of periodontal ligament(PDL) cells on different root surfaces.Methods: The attachment and proliferation of PDL cells on root surfaces of extracted teeth with or without periodontal disease was studied using cell culture and scanning electronic microscopy.Results: The PDL cells attached more on root surface of normal teeth(Group N) than on affected teeth(Group P) either with or without addition of PDGF-BB(P0.05).Compared with controls(Group C),PDGF-BB(Group S) stimulated the attachment of PDL cells both on normal root surface(P0.01) and affected root surface(P0.05).The rates of PDL cell proliferation were 80% and 50% respectively on groups NC and PC without PDGF-BB,and when PDGF-BB was added,rates of PDL cell proliferation in groups NS and PS were 249.4% and 213.09%.Compared with controls(Group C),PDGF-BB significantly stimulated the proliferation of PDL cells both on normal root surface(P0.01) and affected root surface (P0.01).As shown by scanning electronic microscopy,PDL cells on affected root surface were less in quantity,slender in shape,with inadequate extension of cellular dendrites and shrinkage of cell borders.Stimulation with PDGF-BB markedly improved the cell attachment to the root surface and numbers of the cells.Conclusions: PDGF-BB appeared to be a positive growth factor to promote the attachment and proliferation of PDL cells.
【Fund】: 广州市科技局资助项目(1999-J-008-01)
【CateGory Index】: R78
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