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《Academic Journal of Guangzhou Medical College》 2008-01
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Antitumor Effects of Quercetin in P388 Leukemia Mice

YAO Miao-miao, LAI Yong-hong, ZHAI Ying-ying (Department of Pediatrics, First Affiliated Hospital , Guangzhou Medical College, Guangzhou 510120, China)  
Objective:To investigate the antitumor effects of Quercetin (QUE) in P388 leukemia mice. Methods:80 DBA/2 mice bearing transplanted leukemia P388 cells were randomly divided into 4 groups: blank control group, vehicle control group, low-dose QUE group and high-dose QUE group (n=20 each). After the last administration, 10 mice of each group were sampled, killed and collected for ascites. The ascites cells were counted and evaluated for alterations in morphology after AO/PI staining. Flow cytometry was used to analyze cell cycle and cell apoptosis ratio. Pathological changes in bone marrow smears, sections of heart, liver, spleen and kidney tissues were studied under a light microscope. The survival length of the remaining mice was recorded. Results:Administration of QUE significantly prolonged the mean survival length in P388 leukemia mice (P0.05), with even longer survival time in the high-dose than in the low-dose group (P0.05). After sacrifice on day 7, no visible ascites was found in the high-dose QUE group. Compared with the control group, the low-dose QUE group showed remarkably fewer ascites cells, lower ratio of cells at G0-G1phases, higher ratio of cells at S phase, as well as higher rate of apoptotic P388 cells (P0.05). There were no obvious changes in bone marrow slides and heart, liver, spleen, kidney pathological sections in all groups. Conclusion:QUE is shown to prolong the survival length, cause growth inhibition and apoptosis of ascites cells in P388 leukemia mice.
【Fund】: 广东省自然科学基金(5002733)
【CateGory Index】: R733.7
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