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Effect of calcium antagonists in prevention portal hypertension of crrhosis by inhibiting the enzymatic activity of nitric oxide synthase

Wang Hai, Zhou Huaiwen, Yu Xiuzhuan. Department of General Surgery Affiliated Hospital,Guiyang Medical College,550004  
Objective To investigate the mechanism of calciam antagonists that inhibited hepatic fibrosis and to improve the portal venous high dynamic circulation Methods The study was divided into three group the Nos enzymatic activity in hepatic tissue and NO activity in serum were determined.The portal venous flow (PVF), portal venous pressure (PVP),portal venous resistance (PVR) and pathologic examination of liver from three groups were tested.Results Tetrandrine of calcium antagonists was significantly to inhibite the Nos enxymatic activity and NO production and to decrease PVP and PVF. Tetrandrine can prevent the necrosis of hepatic cells and delaying the development of hepatic fibrosis.Conclusion The main preventing mechanism of cirrhosis and portal hypertension was inhibiting the Nos enzymatic activity and No production by calcium antagonists.
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