Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《GUIZHON MEDICAL JOURNAL》 2000-01
Add to Favorite Get Latest Update

Effect of calcium antagonists in prevention portal hypertension of crrhosis by inhibiting the enzymatic activity of nitric oxide synthase

Wang Hai, Zhou Huaiwen, Yu Xiuzhuan. Department of General Surgery Affiliated Hospital,Guiyang Medical College,550004  
Objective To investigate the mechanism of calciam antagonists that inhibited hepatic fibrosis and to improve the portal venous high dynamic circulation Methods The study was divided into three group the Nos enzymatic activity in hepatic tissue and NO activity in serum were determined.The portal venous flow (PVF), portal venous pressure (PVP),portal venous resistance (PVR) and pathologic examination of liver from three groups were tested.Results Tetrandrine of calcium antagonists was significantly to inhibite the Nos enxymatic activity and NO production and to decrease PVP and PVF. Tetrandrine can prevent the necrosis of hepatic cells and delaying the development of hepatic fibrosis.Conclusion The main preventing mechanism of cirrhosis and portal hypertension was inhibiting the Nos enzymatic activity and No production by calcium antagonists.
【CateGory Index】: R575.2
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 1 Hits
1 Guo Yuting,Zhon Huaiwen,Yu xiouzuan,et al.The 44th the PLA hospital, Guiyang 550009;Effect and clinical significance of nitric oxide on hepatic injury of obstructive jaundice[J];Guizhou Medical Journal;2004-03
【Citations】
Chinese Journal Full-text Database 3 Hits
1 Liu Yulan; et al(Institute of Hepatology, People's Hospital of Beijing Medical University,Beijing 100044);The effects of calcium antagonists on 3T6 fibroblasts[J];BEIJING MEDICAL JOURNAL;1996-01
2 Zhang Jian, Zhou Huaiwen. Department of Surgery,Affiliated Hospital of Guiyang Medical College,Guiyang 550001.;Nitric oxide in pathogenesis of cirrhotic portal hypertension in rats and its hemodynamic effects[J];Chiese Journal of Surgery;1998-05
3 WangChenbing,ShenWen-mei,TianYaping,etal.DepartmentofBiochemistry,PLAGeneralHospital,Beijing100853;Measurementofnitrateinserumbyactivatedcadmiumreductionmethod[J];CHINESE JOURNAL OF MEDICAL LABORATORY SCIENCES;1996-05
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Li Feng,Zhang Xiaoming,Zhang Yun,Ye Chuanhui,Cheng Qingli (Department of TCM,Xijing Hospital,Fourth Military Medicial University,PLA,Xi’an 710032,China);EFFECT OF SHENKANG INJECTION ON LEVEL OF ET 1 AND NO SECRETION IN CULTURED GLOMERULAR MESANGIAL CELL[J];JOURNAL OF ANHUI TRADITIONAL CHINESE MEDICAL COLLEGE;2000-02
2 LI Wen gang 1,2 ,ZHANG Xue wen 2,Heer Si tai 2,HU Su xian 3(1. Institute of Hepatobiliary Surgery,General Hospital of PLA,Beijing 100853,China; 2. Department of General Surgery,China Japan Union Hospital, Jinlin University, Changchun130031,China;3.Department of Internal Medicine, Tianjin Harbor Hospital,Tianjin 300456,China);Establishment of fatty liver model of rats[J];Journal of Jilin University of (Medicine Edition);2004-02
3 LU Ding-bo,Zhang Chi-zhi,YAN Xue-sheng,XIAO Lin(Hubei Hospital of Traditional Chinese Medicine,Wuhan 430061,China);Effect of Ruhuang preparation on endotoxin and intestinal defence function of cirrhotic rats[J];China Journal of Traditional Chinese Medicine and Pharmacy;2008-09
4 LI Zhigang,YANG Jinxiang,XIE Chunguang,et al(Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine,Beijing,100700,China)Abstrac:Objective: To study the effects of Ganxinning on TGF-β1 and Smad3 expressions of the experimental hepatic fibrosis induced by carbon tetrachloride(CCl4) in rats,and to explore its anti-fibrotic molecular mechanism.Methods:Sixty-Eight male SD rats were rando mLy divided into 5 groups: normal group(N group,11 rats),model group M group,15 rats),positive control group(PC group,14 rats),high dose of Ganxinning group(GXNh group,14 rats)and low dose of Ganxinning group(GXNl group,14 rats).The rats of M,PC,GXNh and GXNl group were disposed with mixture of CCl4 and peanut for inducing liver fibrosis,sc twice a week,at the same time which were feeded with high-fat and low-albumen food and 30% alcohol.The GXNh or GXNl group was also treated with high dose or low dose of Ganxinning,respectively 2.6g/100g· mL/d or 0.65g/100g? mL/d,ig once a day;the PC group was treated with colchicines,ig once a day;the M group were given singly-distilled water,ig once a day;the N group were not disposed.At the end of 6 weeks all the survived rats were sacrificed.The pathological changes of liver were observed by H-E staining,TGF-β1 mRNA and Smad-3 mRNA were detected by RT-PCR.Results:In comparison with model group,the levels of TGF-β1mRNA were significantly decreased after treatment with Ganxinning.Meanwhile,the levels of Smad-3 mRNA was also down-regulated.The pathological changes of liver tissues in Ganxinning groups were also markedly alleviated.Conclusion:Ganxinning significantly inhibit the development of liver fibrosis in rats induced by CCl4,and its underlying mechanism might relate to decreasing the expression of TGF-β1 and Smad-3.;Effects of Traditional Chinese Medicine Ganxinning on TGF-β1/Smad Signaling Pathway in Carbon Tetrachloride-induced Hepatic Fibrosis of Rats[J];Journal of Chengdu University of Traditional Chinese Medicine;2009-02
5 JIANG Yong-Pei,WANG Sheng-Chun,YANG Chun-E,LUO Hong-Han and LI Mm Department of Pharmacy,Xijing Hospital;The effect of wulingwan on experimental liver cirrhosis in rats[J];Journal of The Fourth Military Medical University;1993-03
6 CHU Yan-Kui; WU Jin-Sheng; GAO De-Ming;WANG Xin(Department of General Surgery, Tangdu Hospital,Fourth Military Medical University, Xi'an 710038,China);Plasma TNF levels during the formation of liver cirrhosis and portal hypertension in rats[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;1999-02
7 LI Peng-Chao1, LU Jian-Guo1, MA Qing-Jiu1, QIAO Wei1, LUO Wen21Department of General Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China, 2Department of Ultrasound Diagnosis, Xijing Hospital, Fourth Military Medical University, Xi'an 710033, China;Changes of hemodynamics and portal vein pressure in the progression of portal hypertension in rats[J];Journal of the Fourth Military Medical University;2007-05
8 YAN Li1, LIU Jing-Mei2, QIAO Wei3, SONG Jian1, WANG Qun-Ying1, ZHONG Hui-Min1 1Department of Gastroenterology, PLA 401 Hospital, Qingdao 266071, China, 2Institute of Gastrointestinal Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an 710033, China, 3Department of Hepatobiliary Surgery, Railway Central Hospital, Xi'an 710054, China;Establishment of liver cancer model based on liver cirrhosis in rats[J];Journal of the Fourth Military Medical University;2007-13
9 Jin Feng,Zhang Jie,Yuan Fang,et al.Department of gastroenterology,The 476th Hospital of PLA,Fuzhou 350002,China;Study on method of inducing cirrhotic model in cats by carbon tetrachloride[J];Fujian Medical Journal;2003-05
10 Si Zhaoxue, Jin Shiying, Wu Dingbiao (Guangzhou Medical College, PLA. Guangzhou, 510315);Histopathological study on inspection of tongue vessels of rats with liver cirrhosis and venous congestion[J];;1996-01
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Liu Peng 1, Li Kaizong 1, Fu Youchi 1, Wang Jicun 2, Zhou Qun 1, Wang Boyun 3 1Department of Hepatobiliary Surgery, 2Department of Digestive Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an 710033 3Department of Pathol;Experimental study on effects of NO on hepatic injury of rats with obstructive jaundice[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;1996-05
2 Lei Zhengming,Li Jing,Yang Wenjun,et al. Departemt of Hepatobiliary Surgery,Affiliated Hospital of Luzhou Medical College,Luzhou 646000;CHANGE AND IT'S SIGNIFICANCE OF SERUM NITRIC OXIDE AND ENDOTHELIN-1 LEVEL IN PATIENTS WITH OBSTRUCTION JAUNDICE.[J];Journal of Hepatobiliary Surgery;2001-05
3 YAN Dong wang,ZHANG Bing yan,WANG Bing huang,et al.Departement of General Surgery.An Qing Municipal Hospital,Anhui,246003,P.R.China);THE EFFECT OF PLATELET-ACTIVATING FACTOR ON CELLUAR IMMUNITY WITH OBSTRUCTIVE JAUNDICE.[J];Journal of Hepatobiliary Surgery;2003-06
4 Wang Chengtai,Dai Kunyang,Lin Qingtian,et al.Department of Surgery,Shanghai Sixth Hospital,Shanghai,200233;Effects of endogenous nitric oxide inhibition on the hemodynamic changes of cirrhotic portal hypertensive rats[J];JOURNAL OF HEPATOPANCREATOBILIARY SURPERY;1999-04
5 Peng Bi cun,YUAN Wen qing,ZHANG ming liang (1.Department of Internal Medicine , Daye People's Hospital, Daye 435100, Hubei; 2.The Second Affiliated Hospital of Nanhua University, Hengyang 421001, Hunan, China);Distribution and Activity of Nitric Oxide Synthase in the Tissues of Portal Hypertensive Rats caused by Hepatic Cirrhosis[J];Hunan Medical Journal;2002-03
6 YE Chun-hua, LIU Xun-yang(Department of General Surgery,the Third Xiangya Hospital,Central South University,Changsha,410013,China);Study on Method of Inducing Hepatic Cirrhosis Model in Rats by Carbon Tetrachloride[J];Journal of Elinical Research;2005-05
7 LI Qing-ping LU Ze-an Rao Man-ren (Department of Cardiovescular Pharmacology Nanjing Medical University Nanjing 210029 China);Protective effect of tetrandrine on injuries of myocardial stunning in rabbits[J];BASIC MEDICAL SCIENCES AND CLINICS;2000-05
8 Fan Lieying; Kong Xiantao; Gao Feng;(Changzheng Hospital,Second Military Medical University , Shanghai 200003);STUDIES-ON TETRANDRINE AGAINST EAPERIMENTAL LIVER FIBROSIS[J];MEDICAL JOURNAL OF CHINESE PEOPLE'S LIBERATION ARMY;1994-06
9 Zhou Dinghua, Ying Dajun, Zhu Chuhong, Mi Jianhong, Song Lin, Sun Jiansen (Department of Anatomy, Third Military Medical University, Chongqing 400038);MORPHOLOGICAL BASIS OF RAT MODEL WITH PORTAL HYPERTENSION AND ESOPHAGEAL VARICES[J];CHINESE JOURNAL OF ANATOMY;1999-02
10 Zhao Yuzhen, et al;Effect of ligusticum wallichii on GSH-PX activity of the heart and liver in the elderly mice[J];Heilongjiang Medicine and Pharmacy;1998-04
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 Wang Tianran,Zeng Xiangyuan,Hu Xiaoli,et al.General Hospital of Chengdu Military Area,Chengdu,Sichuan 610083,China;Studies On The Hemorheology In Rrabbits With Reversible Obstructive Jaundice.[J];Sichuan Medical Journal;2006-09
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Li Ping Department of Medicine,Zhongshan Hospital,Shanghai First Medical College;QUANTITATIVE DETERMINATION OF ENDOTOXIN IN BLOOD,URINE,ASCITES,SPINAL FLUID AND BIOTIC AGENTS-MODIFIED LLT WITH CHROMOGENIC SUBSTRATE[J];;1985-01
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved