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《Guizhon Medical Journal》 2000-06
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Study on the main pharmacodynamics and acute toxicity of eucommia leaves electuary

Hunag Wuguang, Zeng Qingzhou, Pan Zhengxing, Tang Jikun, et al. Guizhou Provincial Institute of Drug Control, Guiyang, 550004  
Objective To study the main pharmacodynamics and acute toxicity of eucommia leaves electuary. Methods The effect of eucommia leaves electuary on the blood pressure of anesthetized cats was measured with RM-6000 four channel physiological recorder. The effect of eucommia leaves electuary on pituitrin was observed in uterine smooth muscle of rats in vitro. The protection of growth of the fetus of eucommia leaves electuary was observed in the incomplete abortion model caused by pituitrin in mouse. The acute toxicity of eucommia leaves electuary administered orally was observed. Results Eucommia leaves electuary can decrease significantly the blood pressure slowly and persistently in anesthetized cats and resist the intensive constract caused by pituitrin. It can decrease the number of abortion caused by pituitrin, while the number of birth increased. The effect of acute toxicity of eucommia leaves elecuary was not found even if mouse was administered by gavage maximum tolerable dose. Conclusion Eucommia leaves electuary can significantly decrease blood pressure and protect growth of the fetus.
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