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《Guizhon Medical Journal》 2001-12
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Apolipoprotein E polymorphism in patients with end stage renal failure

Huang Zhaohui, Wu Zhongming, Li Lija, et al. Department of Nephrology, The first hospital of Guiyang, Guiyang 550002  
Objective In order to confirm the tendency of heredity in end stage renal failure(ESRF), and to find out the related genes. Methods ApoE genetic polymorphism was analyzed in 94 patients with ESRF(those patients had chronic glomerulonephritis), and 108 normal control. Results The frequencies of ApoE2/3 genotype and ε2 allele were significantly higher in ESRF patients than those in normal control(ApoE 2/3 : 31.91% vs 13.89%, P 0.05; ε2:23.94% vs 10.65%, P 0.05), while the frequency of ApoE 2/3 genotype and ε3 allele were much lower in ESRF compared with normal control(ApoE 2/3 : 50% vs 70.37%, P 0.05; ε3: 69.15% vs 82.41%, P 0.05). Conclusion ApoE gene polymorphism is associated with the development of chronic renal failure and may be significant for progression of renal disease.
【Fund】: 贵阳市科技基金资助项目 (No .19990 70 1)
【CateGory Index】: R692.5
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