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《Guizhou Medical Journal》 2003-03
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Effects of aprotinin on lung protection at cardiopulmonary bypass patients

Zou Zongwang,Feng Jin,Xiang Daokang,et al. Department of Cardiac Surgery,Wenzhou The 3th Hospital,Wenzhou 325000  
Objective To investigate the effects of aprotinin on lung protection at cardiopulmonary bypass(CPB) patients. Methods 24 cases rheumatic heart valve disease patients underwent valve replacement with cardiopulmonary bypass were divided into test group and control group. The paramenters of the complement 3 (C 3),complement 4 (C 4); leukocyte count, difference of transpulmonary olymorphonuclear leukocyte were measured during the perioperative period and the time of used respirator were recorded.Results The changes of the difference of transpulmonary polymorphonuclear leukocyte in test group were significantly lower on 5min, 10min, 15min after aorta was unclamped than those in control group ( P 0.05 or P 0.01) and the changes in the both groups during and after operation were significantly higher than before CPB( P 0.01). Conclusion Aprotinin has a better inhabitor at systemic inflammatory responses syndrome and advantageous effects on lung protection at cardiopulmonary bypass patients.
【Fund】: 温州市科委资助项目编号 :S2 0 0 0A3 6 3
【CateGory Index】: R654.2
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