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《Guizhou Medical Journal》 2004-03
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Effect and clinical significance of nitric oxide on hepatic injury of obstructive jaundice

Guo Yuting,Zhon Huaiwen,Yu xiouzuan,et al.The 44th the PLA hospital, Guiyang 550009  
Objective To investigate the effects and clinical significance of nitric oxide(NO) on hepatic injury of patients with obstructive jaundice. Methods Thirty patients with obstructive jaundice were selected as experimental group and 30 cases with cholelithiasis as control group.Serum nitrite/nitratre levels in liver tissue was measured as an index for nitric oxide generation in patients.Serum GOT?GPT?TBil?tumor necrosis factor(TNF)?albumin and blood plasma endotoxin were observed.The level of nitrite/nitratre was assailed by nitric acid reductase process.The level of TNF was assailed by radioimmunoassay (RIA).A small sample of liver was obtained in patients with obstructive jaundice. Histo-morphology was observed.Hepatocellular nicrosis area was calculated by computer photograph assayor at HE stain. Results (1)The levels of NO - 2/NO - 3?TNF?ENDOTOXIN in experimental group were significantly higher than the control group (P0.01), (2)There was positive relationship between the hepatocellular necrosis area and the level of NO - 2/NO - 3.(3)There was positive relationship among serum NO - 2/NO - 3?TBil?GOT?GPT in experiment group.Conclusion Nitric oxide participates in the progress of hepatic injury of patients with obstructive jaundice and play an important role.
【CateGory Index】: R575
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